Ayşen Helvacı1, Besime Copur1, Mine Adaş1. 1. Clinic of 2 Internal Medicine, Okmeydanı Training and Research Hospital, İstanbul, Turkey.
Abstract
OBJECTIVE: To determine the correlation between left ventricular mass index and calcium metabolism in patients with essential hypertension. STUDY DESIGN: Cross sectional case-control study. MATERIAL AND METHODS: Twenty-seven patients with essential hypertension and 20 healthy individuals were compared with respect to calciotropic hormones, left ventricular mass index (LVMI), and urinary and serum biochemical parameters. The correlations between parathormone, vitamin D, and calcitonin levels and LVMI and blood pressure elevation were determined. RESULTS: The parathormone level was significantly higher (p=0.006) and vitamin D level was significantly lower (p=0.01) in the patient group compared with the control group. However, the two groups were similar in terms of albumin-corrected calcium levels, which were within the normal range (p=0.988). The serum sodium (p=0.014) and urinary calcium (p=0.003) levels and LVMI (p<0.01) were also significantly higher in the patient group. No significant correlations were determined between ambulatory blood pressure and parathormone and vitamin D levels, but a significant correlation was found between LVMI and parathormone level (p=0.06) in hypertensive patients. CONCLUSION: Essential hypertension alters calcium metabolism, causing calciuresis by hypernatremia. Parathormone release increases to compensate for this, and leads to protein synthesis, which in turn provokes the development of myocardial hypertrophy.
OBJECTIVE: To determine the correlation between left ventricular mass index and calcium metabolism in patients with essential hypertension. STUDY DESIGN: Cross sectional case-control study. MATERIAL AND METHODS: Twenty-seven patients with essential hypertension and 20 healthy individuals were compared with respect to calciotropic hormones, left ventricular mass index (LVMI), and urinary and serum biochemical parameters. The correlations between parathormone, vitamin D, and calcitonin levels and LVMI and blood pressure elevation were determined. RESULTS: The parathormone level was significantly higher (p=0.006) and vitamin D level was significantly lower (p=0.01) in the patient group compared with the control group. However, the two groups were similar in terms of albumin-corrected calcium levels, which were within the normal range (p=0.988). The serum sodium (p=0.014) and urinary calcium (p=0.003) levels and LVMI (p<0.01) were also significantly higher in the patient group. No significant correlations were determined between ambulatory blood pressure and parathormone and vitamin D levels, but a significant correlation was found between LVMI and parathormone level (p=0.06) in hypertensivepatients. CONCLUSION: Essential hypertension alters calcium metabolism, causing calciuresis by hypernatremia. Parathormone release increases to compensate for this, and leads to protein synthesis, which in turn provokes the development of myocardial hypertrophy.
Entities:
Keywords:
Essential hypertension; calcium metabolism; left ventricular hypertrophy; parathormone
Authors: A Piovesan; N Molineri; F Casasso; I Emmolo; G Ugliengo; F Cesario; G Borretta Journal: Clin Endocrinol (Oxf) Date: 1999-03 Impact factor: 3.478