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Literature DB >> 9383085

On the number of ancestors to a DNA sequence.

Abstract

If homologous sequences in a population are not subject to recombination, they can all be traced back to one ancestral sequence. However, the rest of our genome is subject to recombination and will be spread out on a series of individuals. The distribution of ancestral material to an extant chromosome is here investigated by the coalescent with recombination, and the results are discussed relative to humans. In an ancestral population of actual size 1.3 million a minority of <6.4% will carry material ancestral to any present human. The estimated actual population size can be even higher, 5 million, reducing the percentage to 1.7%.

Entities: Species

Mesh：

Substances：
DNA

Year: 1997 PMID： 9383085 PMCID： PMC1208266

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

6 in total

1. Properties of a neutral allele model with intragenic recombination.

Authors: R R Hudson
Journal: Theor Popul Biol Date: 1983-04 Impact factor: 1.570

2. Statistical properties of the number of recombination events in the history of a sample of DNA sequences.

Authors: R R Hudson; N L Kaplan
Journal: Genetics Date: 1985-09 Impact factor: 4.562

3. On the number of members of the genus Homo who have ever lived, and some evolutionary implications.

Authors: K M Weiss
Journal: Hum Biol Date: 1984-12 Impact factor: 0.553

4. The use of sample genealogies for studying a selectively neutral m-loci model with recombination.

Authors: N Kaplan; R R Hudson
Journal: Theor Popul Biol Date: 1985-12 Impact factor: 1.570

5. Mitochondrial DNA and human evolution.

Authors: R L Cann; M Stoneking; A C Wilson
Journal: Nature Date: 1987 Jan 1-7 Impact factor: 49.962

6. Divergence time and population size in the lineage leading to modern humans.

Authors: N Takahata; Y Satta; J Klein
Journal: Theor Popul Biol Date: 1995-10 Impact factor: 1.570

6 in total

11 in total

10. Estimating divergence time and ancestral effective population size of Bornean and Sumatran orangutan subspecies using a coalescent hidden Markov model.

Authors: Thomas Mailund; Julien Y Dutheil; Asger Hobolth; Gerton Lunter; Mikkel H Schierup
Journal: PLoS Genet Date: 2011-03-03 Impact factor: 5.917

On the number of ancestors to a DNA sequence.

1. Properties of a neutral allele model with intragenic recombination.

2. Statistical properties of the number of recombination events in the history of a sample of DNA sequences.

3. On the number of members of the genus Homo who have ever lived, and some evolutionary implications.

4. The use of sample genealogies for studying a selectively neutral m-loci model with recombination.

5. Mitochondrial DNA and human evolution.

6. Divergence time and population size in the lineage leading to modern humans.

1. The size distribution of homozygous segments in the human genome.

2. The coalescent with gene conversion.

3. Recombination, balancing selection and phylogenies in MHC and self-incompatibility genes.

4. Consequences of recombination on traditional phylogenetic analysis.

5. Common 5' beta-globin RFLP haplotypes harbour a surprising level of ancestral sequence mosaicism.

6. Partitioning, duality, and linkage disequilibria in the Moran model with recombination.

7. The effect of population history on the lengths of ancestral chromosome segments.

8. On recombination-induced multiple and simultaneous coalescent events.

9. Single-crossover recombination and ancestral recombination trees.

10. Estimating divergence time and ancestral effective population size of Bornean and Sumatran orangutan subspecies using a coalescent hidden Markov model.