| Literature DB >> 937182 |
S L Meyer, G C Curry, M S Donsky, D B Twieg, R W Parkey, J T Willerson.
Abstract
The influence of dobutamine on hemodynamics and coronary blood flow was studied in patients after routine cardiac catheterization. The data demonstrated that dobutamine is a powerful inotropic agent at a dose that has a relatively small influence on heart rate. In patients without coronary artery disease dobutamine greatly increased coronary arterial perfusion. In patients with severe coronary artery diseases dobutamine resulted in a much smaller increase in coronary perfusion, and the pattern of perfusion became more inhomogeneous. The results suggest that dobutamine has a potential inotropic value but raise concern about its influence on regional myocardial perfusion in patients with serious coronary artery disease.Entities:
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Year: 1976 PMID： 937182 DOI： 10.1016/0002-9149(76)90070-9
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778