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Literature DB >> 9371642

A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.

R C Desrosiers¹, V G Sasseville, S C Czajak, X Zhang, K G Mansfield, A Kaur, R P Johnson, A A Lackner, J U Jung.

Abstract

A herpesvirus that is related to but distinct from the Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHV than to those of any other herpesvirus. This rhesus monkey herpesvirus replicated lytically and to high titers in cultured rhesus monkey fibroblasts. Antibody testing revealed a high prevalence for at least 10 years in our rhesus monkey colony and a high prevalence in two other colonies that were tested. Thus, rhesus monkeys naturally harbor a virus related to KSHV, which we have called RRV, for rhesus monkey rhadinovirus.

Entities: Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9371642 PMCID： PMC230286

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

40 in total

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120 in total

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7. Two distinct gamma-2 herpesviruses in African green monkeys: a second gamma-2 herpesvirus lineage among old world primates?

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