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Literature DB >> 9371370

Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells.

J R Lokensgard¹, G Gekker, S Hu, A F Arthur, C C Chao, P K Peterson.

Abstract

Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.

Entities: Chemical Species

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Year: 1997 PMID： 9371370 PMCID： PMC164165

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

32 in total

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5 in total

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2. Adverse event following live attenuated chikungunya vaccine in a cynomolgus macaque with pre-existing chronic hydrocephalus.

Authors: Tiffany A Peterson; Andrew G MacLean; Kasi E Russell-Lodrigue; Peter J Didier; Scott C Weaver; Chad J Roy
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