Literature DB >> 918669

Benzodiazepine receptor: demonstration in the central nervous system.

H Möhler, T Okada.   

Abstract

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.

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Year:  1977        PMID： 918669     DOI： 10.1126/science.918669

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  201 in total

Review 1.  The peripheral benzodiazepine receptors: a review.

Authors:  A Beurdeley-Thomas; L Miccoli; S Oudard; B Dutrillaux; M F Poupon
Journal:  J Neurooncol       Date:  2000       Impact factor: 4.130

2.  Benzodiazepine receptors in the brain as affected by different experimental stresses: the changes are small and not undirectional.

Authors:  C Braestrup; M Nielsen; E B Nielsen; M Lyon
Journal:  Psychopharmacology (Berl)       Date:  1979-11       Impact factor: 4.530

Review 3.  GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam.

Authors:  Raman Sankar
Journal:  CNS Drugs       Date:  2012-03-01       Impact factor: 5.749

Review 4.  Overview--flavonoids: a new family of benzodiazepine receptor ligands.

Authors:  J H Medina; H Viola; C Wolfman; M Marder; C Wasowski; D Calvo; A C Paladini
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

5.  Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior.

Authors:  E M Weerts; L G Miller; K E Hood; K A Miczek
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

6.  Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats.

Authors:  M Hollander-Jansen; J Dingemanse; M W Langemeijer; M Danhof
Journal:  Pharm Res       Date:  1989-07       Impact factor: 4.200

7.  Benzodiazepine receptors increase in post-mortem brain of chronic schizophrenics.

Authors:  Y Kiuchi; T Kobayashi; J Takeuchi; H Shimizu; H Ogata; M Toru
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1989

8.  "Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.

Authors:  E M Weerts; W Tornatzky; K A Miczek
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Central effects in man of the novel schistosomicidal benzodiazepine meclonazepam.

Authors:  C O'Boyle; R Lambe; A Darragh
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

10.  A comparison between chlordiazepoxide and CL 218,872, a synthetic non-benzodiazepine ligand for benzodiazepine receptors, on serotonin and catecholamine turnover in brain.

Authors:  J F McElroy; R S Feldman; J S Meyer
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530
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