Literature DB >> 9371365

Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244.

L Bret1, E B Chaibi, C Chanal-Claris, D Sirot, R Labia, J Sirot.   

Abstract

A novel inhibitor-resistant TEM (IRT) beta-lactamase was detected in an Escherichia coli isolate resistant to amoxicillin-clavulanate and susceptible to cephalothin. The substrate and inhibitor profiles of this beta-lactamase were similar to those of IRT-1 and IRT-2. The novel IRT's bla gene was sequenced, and the deduced amino acid sequence showed the amino acid replacement Arg for His-244 of the TEM-1 sequence. Substitutions for Arg-244 have been reported in three TEM-1 mutants: IRT-1 (which corresponds to TEM-31) (Cys), IRT-2/TEM-30 (Ser), and TEM-41 (Thr). We designated this novel beta-lactamase, which corresponds to TEM-51, IRT-15.

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Year:  1997        PMID： 9371365      PMCID： PMC164160     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 beta-lactamase genes.

Authors:  C Chanal; M C Poupart; D Sirot; R Labia; J Sirot; R Cluzel
Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191

2.  Beta-lactamase TEM1 of E. coli. Crystal structure determination at 2.5 A resolution.

Authors:  C Jelsch; F Lenfant; J M Masson; J P Samama
Journal:  FEBS Lett       Date:  1992-03-09       Impact factor: 4.124

3.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

4.  Small plasmids are involved in amoxicillin-clavulanate resistance in Escherichia coli.

Authors:  J L Martinez; M F Vicente; A Delgado-Iribarren; J C Perez-Diaz; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

5.  Sequence of the genes blaT-1B and blaT-2.

Authors:  S Goussard; P Courvalin
Journal:  Gene       Date:  1991-06-15       Impact factor: 3.688

6.  Characterization of an inhibitor-resistant enzyme IRT-2 derived from TEM-2 beta-lactamase produced by Proteus mirabilis strains.

Authors:  L Bret; C Chanal; D Sirot; R Labia; J Sirot
Journal:  J Antimicrob Chemother       Date:  1996-08       Impact factor: 5.790

7.  Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.

Authors:  R Labia; J Andrillon; F Le Goffic
Journal:  FEBS Lett       Date:  1973-06-15       Impact factor: 4.124

8.  Factors determining resistance to beta-lactam combined with beta-lactamase inhibitors in Escherichia coli.

Authors:  J A Reguera; F Baquero; J C Pérez-Díaz; J L Martínez
Journal:  J Antimicrob Chemother       Date:  1991-05       Impact factor: 5.790

9.  Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.

Authors:  M Delaire; R Labia; J P Samama; J M Masson
Journal:  J Biol Chem       Date:  1992-10-15       Impact factor: 5.157

10.  Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.

Authors:  G Vedel; A Belaaouaj; L Gilly; R Labia; A Philippon; P Névot; G Paul
Journal:  J Antimicrob Chemother       Date:  1992-10       Impact factor: 5.790
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  18 in total

1.  Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.

Authors:  Sergei Vakulenko; Dasantila Golemi
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

2.  Quantifying nonspecific TEM beta-lactamase (blaTEM) genes in a wastewater stream.

Authors:  Karen L Lachmayr; Lee J Kerkhof; A Gregory Dirienzo; Colleen M Cavanaugh; Timothy E Ford
Journal:  Appl Environ Microbiol       Date:  2008-11-07       Impact factor: 4.792

3.  Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase.

Authors:  David C Marciano; Nicholas G Brown; Timothy Palzkill
Journal:  Protein Sci       Date:  2009-10       Impact factor: 6.725

4.  Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.

Authors:  V Leflon-Guibout; V Speldooren; B Heym; M Nicolas-Chanoine
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

Review 5.  Past and Present Perspectives on β-Lactamases.

Authors:  Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

6.  Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytoca.

Authors:  H Bermudes; F Jude; E B Chaibi; C Arpin; C Bebear; R Labia; C Quentin
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

7.  Crystal structure of a preacylation complex of the β-lactamase inhibitor sulbactam bound to a sulfenamide bond-containing thiol-β-lactamase.

Authors:  Elizabeth A Rodkey; Sarah M Drawz; Jared M Sampson; Christopher R Bethel; Robert A Bonomo; Focco van den Akker
Journal:  J Am Chem Soc       Date:  2012-09-26       Impact factor: 15.419

8.  Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.

Authors:  P D Stapleton; K P Shannon; G L French
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

9.  Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.

Authors:  Laura Briñas; Myriam Zarazaga; Yolanda Sáenz; Fernanda Ruiz-Larrea; Carmen Torres
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

10.  Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase.

Authors:  David C Marciano; Jeanine M Pennington; Xiaohu Wang; Jian Wang; Yu Chen; Veena L Thomas; Brian K Shoichet; Timothy Palzkill
Journal:  J Mol Biol       Date:  2008-09-16       Impact factor: 5.469
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