Literature DB >> 9371363

Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.

T Köhler1, M Michea-Hamzehpour, P Plesiat, A L Kahr, J C Pechere.   

Abstract

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.

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Year:  1997        PMID： 9371363      PMCID： PMC164158     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Resistance to pefloxacin in Pseudomonas aeruginosa.

Authors:  M Michea-Hamzehpour; C Lucain; J C Pechere
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

2.  Microbial Selection.

Authors:  V Bryson; W Szybalski
Journal:  Science       Date:  1952-07-18       Impact factor: 47.728

3.  Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.

Authors:  T Köhler; M Michéa-Hamzehpour; U Henze; N Gotoh; L K Curty; J C Pechère
Journal:  Mol Microbiol       Date:  1997-01       Impact factor: 3.501

4.  Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa.

Authors:  K Hirai; S Suzue; T Irikura; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

5.  New norfloxacin resistance gene in Pseudomonas aeruginosa PAO.

Authors:  H Fukuda; M Hosaka; K Hirai; S Iyobe
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191

6.  Resistance of Pseudomonas aeruginosa PAO to nalidixic acid and low levels of beta-lactam antibiotics: mapping of chromosomal genes.

Authors:  M Rella; D Haas
Journal:  Antimicrob Agents Chemother       Date:  1982-08       Impact factor: 5.191

7.  Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa.

Authors:  N Masuda; N Gotoh; S Ohya; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

8.  Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa.

Authors:  T Yoshida; T Muratani; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

9.  Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa.

Authors:  E B Jakics; S Iyobe; K Hirai; H Fukuda; H Hashimoto
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

10.  Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin.

Authors:  X Z Li; D M Livermore; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191
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  55 in total

Review 1.  Mutation frequencies and antibiotic resistance.

Authors:  J L Martinez; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

Review 2.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

3.  Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.

Authors:  Nelson Jumbe; Arnold Louie; Robert Leary; Weiguo Liu; Mark R Deziel; Vincent H Tam; Reetu Bachhawat; Christopher Freeman; James B Kahn; Karen Bush; Michael N Dudley; Michael H Miller; George L Drusano
Journal:  J Clin Invest       Date:  2003-07       Impact factor: 14.808

Review 4.  Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance.

Authors:  Peter Gilbert; Andrew J McBain
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132

5.  On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient.

Authors:  Rutger Hermsen; J Barrett Deris; Terence Hwa
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

6.  Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa.

Authors:  Charlotte Richardot; Paulo Juarez; Katy Jeannot; Isabelle Patry; Patrick Plésiat; Catherine Llanes
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

7.  Genes that enhance the ecological fitness of Shewanella oneidensis MR-1 in sediments reveal the value of antibiotic resistance.

Authors:  Jennifer L Groh; Qingwei Luo; Jimmy D Ballard; Lee R Krumholz
Journal:  Appl Environ Microbiol       Date:  2006-11-17       Impact factor: 4.792

8.  Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.

Authors:  H Mouneimné; J Robert; V Jarlier; E Cambau
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

Review 9.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

10.  Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats.

Authors:  O F Join-Lambert; M Michéa-Hamzehpour; T Köhler; F Chau; F Faurisson; S Dautrey; C Vissuzaine; C Carbon; J Pechère
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191
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