Literature DB >> 9370514

Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?

A Ebringer1, C Thorpe, J Pirt, C Wilson, P Cunningham, C Ettelaie.   

Abstract

Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three bacteria (Acinetobacter calcoaceticus,Ruminococcus albus, and Agrobacter tumefaciens) share sequences with the encephalitogenic peptide of bovine myelin, while three molecules in Escherichia coli show molecular mimicry with host-encoded prion protein. Immune responses against these bacteria at both T and B cell levels may cause neurological tissue injury resembling BSE. The role of these bacteria in BSE, if any, merits further investigation.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9370514      PMCID： PMC1470340          DOI： 10.1289/ehp.971051172

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  23 in total

Review 1.  "Friendly fire" in medicine: hormones, homografts, and Creutzfeldt-Jakob disease.

Authors:  P Brown; M A Preece; R G Will
Journal:  Lancet       Date:  1992-07-04       Impact factor: 79.321

Review 2.  Ileocolonoscopic findings in seronegative spondylarthropathies.

Authors:  H Mielants; E M Veys; C Cuvelier; M de Vos
Journal:  Br J Rheumatol       Date:  1988

3.  Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.

Authors:  B Chesebro; R Race; K Wehrly; J Nishio; M Bloom; D Lechner; S Bergstrom; K Robbins; L Mayer; J M Keith
Journal:  Nature       Date:  1985 May 23-29       Impact factor: 49.962

4.  Serum antibodies to Klebsiella capsular polysaccharides in ankylosing spondylitis.

Authors:  H Sahly; R Podschun; R Sass; B Bröker; J Kekow; W L Gross; U Ullmann
Journal:  Arthritis Rheum       Date:  1994-05

Review 5.  Ankylosing spondylitis is caused by Klebsiella. Evidence from immunogenetic, microbiologic, and serologic studies.

Authors:  A Ebringer
Journal:  Rheum Dis Clin North Am       Date:  1992-02       Impact factor: 2.670

6.  Bacterial antibodies in ankylosing spondylitis.

Authors:  O Mäki-Ikola; K Lehtinen; K Granfors; R Vainionpää; P Toivanen
Journal:  Clin Exp Immunol       Date:  1991-06       Impact factor: 4.330

7.  Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon.

Authors:  W Goldmann; N Hunter; T Martin; M Dawson; J Hope
Journal:  J Gen Virol       Date:  1991-01       Impact factor: 3.891

8.  Neurotoxicity of a prion protein fragment.

Authors:  G Forloni; N Angeretti; R Chiesa; E Monzani; M Salmona; O Bugiani; F Tagliavini
Journal:  Nature       Date:  1993-04-08       Impact factor: 49.962

Review 9.  The Ninth Datta Lecture. Molecular biology of transmissible spongiform encephalopathies.

Authors:  C Weissmann
Journal:  FEBS Lett       Date:  1996-06-24       Impact factor: 4.124

10.  Novel proteinaceous infectious particles cause scrapie.

Authors:  S B Prusiner
Journal:  Science       Date:  1982-04-09       Impact factor: 47.728
View more
  6 in total

1.  Absence of Spiroplasma or other bacterial 16s rRNA genes in brain tissue of hamsters with scrapie.

Authors:  Irina Alexeeva; Ellen J Elliott; Sandra Rollins; Gail E Gasparich; Jozef Lazar; Robert G Rohwer
Journal:  J Clin Microbiol       Date:  2006-01       Impact factor: 5.948

2.  Antibody responses to Acinetobacter spp. and Pseudomonas aeruginosa in multiple sclerosis: prospects for diagnosis using the myelin-acinetobacter-neurofilament antibody index.

Authors:  L E Hughes; S Bonell; R S Natt; C Wilson; H Tiwana; A Ebringer; P Cunningham; V Chamoun; E J Thompson; J Croker; J Vowles
Journal:  Clin Diagn Lab Immunol       Date:  2001-11

Review 3.  Regaining tolerance to a self-antigen by the modified vaccination technique.

Authors:  Arpad Zsigmond Barabas; Chad Douglas Cole; Rene Lafreniere; Donald Mackay Weir
Journal:  Clin Rev Allergy Immunol       Date:  2013-10       Impact factor: 8.667

4.  Autoantibodies to brain components and antibodies to Acinetobacter calcoaceticus are present in bovine spongiform encephalopathy.

Authors:  H Tiwana; C Wilson; J Pirt; W Cartmell; A Ebringer
Journal:  Infect Immun       Date:  1999-12       Impact factor: 3.441

Review 5.  Treatment alternatives of slaughterhouse wastes, and their effect on the inactivation of different pathogens: a review.

Authors:  Ingrid H Franke-Whittle; Heribert Insam
Journal:  Crit Rev Microbiol       Date:  2012-06-13       Impact factor: 7.624

Review 6.  Molecular mimicry and immune-mediated diseases.

Authors:  M B Oldstone
Journal:  FASEB J       Date:  1998-10       Impact factor: 5.191
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.