OBJECTIVE: To measure antibodies to Klebsiella capsular polysaccharides in the sera of HLA-B27 positive patients with ankylosing spondylitis (AS), compared with HLA-B27 positive and HLA-B27 negative healthy control subjects. METHODS: Antibodies were detected by means of an enzyme-linked immunosorbent assay specific for each of the 77 known Klebsiella serotypes. RESULTS: Significantly elevated frequencies and titers of antibodies to capsular polysaccharides K26, K36, and K50 were detected in sera from AS patients, compared with controls. CONCLUSION: These results suggest the predominance of Klebsiella serotypes K26, K36, and K50 in patients with AS.
OBJECTIVE: To measure antibodies to Klebsiella capsular polysaccharides in the sera of HLA-B27 positive patients with ankylosing spondylitis (AS), compared with HLA-B27 positive and HLA-B27 negative healthy control subjects. METHODS: Antibodies were detected by means of an enzyme-linked immunosorbent assay specific for each of the 77 known Klebsiella serotypes. RESULTS: Significantly elevated frequencies and titers of antibodies to capsular polysaccharidesK26, K36, and K50 were detected in sera from AS patients, compared with controls. CONCLUSION: These results suggest the predominance of Klebsiella serotypes K26, K36, and K50 in patients with AS.
Authors: P Toivanen; D S Hansen; F Mestre; L Lehtonen; J Vaahtovuo; M Vehma; T Möttönen; R Saario; R Luukkainen; M Nissilä Journal: J Clin Microbiol Date: 1999-09 Impact factor: 5.948
Authors: H Sahly; R Podschun; T A Oelschlaeger; M Greiwe; H Parolis; D Hasty; J Kekow; U Ullmann; I Ofek; S Sela Journal: Infect Immun Date: 2000-12 Impact factor: 3.441