Literature DB >> 9370064

Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism.

E Gould1, P Tanapat, H A Cameron.   

Abstract

Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

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Year:  1997        PMID： 9370064     DOI： 10.1016/s0165-3806(97)00079-5

Source DB:  PubMed          Journal:  Brain Res Dev Brain Res        ISSN： 0165-3806


  19 in total

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