Literature DB >> 9369106

Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial.

G J Oettlé1.   

Abstract

PURPOSE: This study was undertaken to compare local application of a glyceryl trinitrate ointment with lateral internal sphincterotomy for the treatment of chronic fissure-in-ano. PATIENTS AND METHODS: A sample of 24 consecutive patients with chronic anal fissure was randomly allocated to treatment with sphincterotomy or local glyceryl trinitrate. Patients were followed-up for a median of 22 months.
RESULTS: All 12 patients healed following sphincterotomy; 10 of 12 healed with local glyceryl trinitrate (P = 0.239). There were no recurrences or side-effects in either group.
CONCLUSIONS: Local application of glyceryl trinitrate can avoid surgery in more than 80 percent of patients with chronic anal fissure.

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Year:  1997        PMID： 9369106     DOI： 10.1007/bf02050816

Source DB:  PubMed          Journal:  Dis Colon Rectum        ISSN： 0012-3706            Impact factor:   4.585


  17 in total

Review 1.  Symptomatic care and nitroglycerin in the management of anal fissure.

Authors:  Robin S McLeod; Justin Evans
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Review 2.  Anal fissure: the changing management of a surgical condition.

Authors:  A G Acheson; J H Scholefield
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Review 3.  The use of botulinum toxin for the treatment of gastrointestinal motility disorders.

Authors:  Frank Friedenberg; Satya Gollamudi; Henry P Parkman
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Review 4.  Current concepts in anal fissures.

Authors:  Abraham A Ayantunde; Samuel A Debrah
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Review 5.  A review of chronic anal fissure management.

Authors:  E E Collins; J N Lund
Journal:  Tech Coloproctol       Date:  2007-08-03       Impact factor: 3.781

6.  Towards safer treatments for benign anorectal disease: the pharmacological manipulation of the internal anal sphincter.

Authors:  Oliver M Jones
Journal:  Ann R Coll Surg Engl       Date:  2007-09       Impact factor: 1.891

7.  Lateral internal sphincterotomy is not redundant in the era of glyceryl trinitrate therapy for chronic anal fissure.

Authors:  M Jonas; D N Lobo; A M Gudgeon
Journal:  J R Soc Med       Date:  1999-04       Impact factor: 5.344

8.  Combined approach in the treatment of chronic anal fissures.

Authors:  S Vershenya; J Klotz; A Joos; D Bussen; A Herold
Journal:  Updates Surg       Date:  2015-04-21

Review 9.  Anal fissure (chronic).

Authors:  Richard L Nelson
Journal:  BMJ Clin Evid       Date:  2014-11-12

10.  Lateral internal sphincterotomy versus 0.25 % isosorbide dinitrate ointment for chronic anal fissures: a prospective randomized controlled trial.

Authors:  Kemal Arslan; Bülent Erenoğlu; Osman Doğru; Ersin Turan; Mehmet Ali Eryilmaz; Arif Atay; Said Kökçam
Journal:  Surg Today       Date:  2012-09-09       Impact factor: 2.549
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