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Literature DB >> 15104353

The use of botulinum toxin for the treatment of gastrointestinal motility disorders.

Frank Friedenberg¹, Satya Gollamudi, Henry P Parkman.

Abstract

Botulinum toxin type A is used extensively for the management of gastrointestinal smooth muscle disorders. This review is a comprehensive summary of the current status of this therapy. It includes English-language research from 1966 to 2003 and relevant abstracts from subspecialty meetings from the past 3 years. Botulinum toxin appears to be beneficial for achalasia, gastroparesis, sphincter of Oddi dysfunction, anal fissure and anismus. Very few placebo-controlled trials have been performed despite widespread use of toxin for the past 10 years. Botulinum toxin appears to be safe and side effects are uncommon. Despite uncontrolled data, botulinum toxin is now used for a variety of spastic disorders of GI smooth muscle. In some instances this therapy may preclude the need for more invasive treatments. Controlled trials are needed.

Entities: Disease

Mesh：

Substances：

Year: 2004 PMID： 15104353 DOI： 10.1023/b:ddas.0000017434.53075.80

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

70 in total

1. Effects of previous treatment on results of laparoscopic Heller myotomy for achalasia.

Authors: M G Patti; C V Feo; M Arcerito; M De Pinto; A Tamburini; U Diener; W Gantert; L W Way
Journal: Dig Dis Sci Date: 1999-11 Impact factor: 3.199

2. Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia.

Authors: V Annese; M Basciani; O Borrelli; G Leandro; P Simone; A Andriulli
Journal: Muscle Nerve Date: 1998-11 Impact factor: 3.217

3. Treatment of symptomatic nonachalasia esophageal motor disorders with botulinum toxin injection at the lower esophageal sphincter.

Authors: L S Miller; H P Parkman; T D Schiano; M J Cassidy; R B Ter; M A Dabezies; S Cohen; R S Fisher
Journal: Dig Dis Sci Date: 1996-10 Impact factor: 3.199

4. Long-term results of endoscopic injection of botulinum toxin in elderly achalasic patients with tortuous megaesophagus or epiphrenic diverticulum.

Authors: T Wehrmann; H Kokabpick; V Jacobi; H Seifert; B Lembcke; W F Caspary
Journal: Endoscopy Date: 1999-06 Impact factor: 10.093

5. Long-term efficacy of Botulinum toxin in classical achalasia: a prospective study.

Authors: J Kolbasnik; W E Waterfall; B Fachnie; Y Chen; G Tougas
Journal: Am J Gastroenterol Date: 1999-12 Impact factor: 10.864

6. Pyloric injection of botulinum toxin for treatment of diabetic gastroparesis.

Authors: Dina Ezzeddine; Rajkamal Jit; Neil Katz; Narasimh Gopalswamy; Manoop S Bhutani
Journal: Gastrointest Endosc Date: 2002-06 Impact factor: 9.427

Review 7. Achalasia.

Authors: J C Reynolds; H P Parkman
Journal: Gastroenterol Clin North Am Date: 1989-06 Impact factor: 3.806

The use of botulinum toxin for the treatment of gastrointestinal motility disorders.

1. Effects of previous treatment on results of laparoscopic Heller myotomy for achalasia.

2. Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia.

3. Treatment of symptomatic nonachalasia esophageal motor disorders with botulinum toxin injection at the lower esophageal sphincter.

4. Long-term results of endoscopic injection of botulinum toxin in elderly achalasic patients with tortuous megaesophagus or epiphrenic diverticulum.

5. Long-term efficacy of Botulinum toxin in classical achalasia: a prospective study.

6. Pyloric injection of botulinum toxin for treatment of diabetic gastroparesis.

Review 7. Achalasia.

8. Integrity of cholinergic innervation to the lower esophageal sphincter in achalasia.

9. Symptomatic improvement in achalasia after botulinum toxin injection of the lower esophageal sphincter.

10. Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin.

Review 1. Botulinum Toxin Injection for Treatment of Gastroparesis.

Review 2. Endoscopy in the diagnosis and management of motility disorders.

3. Botulinum toxin A as a treatment for delayed gastric emptying in a dog.

Review 4. Sphincter of Oddi dysfunction: managing the patient with chronic biliary pain.

5. Management of esophageal symptoms following fundoplication.

6. Delayed gastric emptying: whom to test, how to test, and what to do.

7. Safety and efficacy of therapy with botulinum toxin in obesity: a pilot study.

8. Gastrointestinal Uses of Botulinum Toxin.

9. Advances in the management of gastroparesis.

10. Sphincter of Oddi and its dysfunction.