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Literature DB >> 9368086

In vitro antifungal activity of novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and comparison with fluconazole.

Abstract

Thirty-three patient fungal isolates were studied by broth macrodilution methods for susceptibility to novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and fluconazole. MICs (micrograms/ml) ranged widely, but none had lower MICs for Candida albicans or Cryptococcus neoformans than UR-9751. Fluconazole and UR-9751 had the most activity versus other Candida species. Activity was demonstrated versus endemic fungal pathogens. Aspergillus species were generally resistant, although modest activity was seen. UR-9746 and UR-9751 are active in vitro, with a potency comparable to that of fluconazole.

Entities: Chemical Species

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Year: 1997 PMID： 9368086 DOI： 10.1016/s0732-8893(97)00104-1

Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803

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Cited

13 in total

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Journal: Antimicrob Agents Chemother Date: 2017-03-24 Impact factor: 5.191

3. Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis.

Authors: Perparim Kamberi; Raymond A Sobel; Karl V Clemons; Andreas Waldvogel; Joan M Striebel; Paul L Williams; David A Stevens
Journal: Antimicrob Agents Chemother Date: 2006-12-18 Impact factor: 5.191

4. Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens.

Authors: D A Stevens
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

10. Effect of Media Modified To Mimic Cystic Fibrosis Sputum on the Susceptibility of Aspergillus fumigatus, and the Frequency of Resistance at One Center.

Authors: David A Stevens; Richard B Moss; Cathy Hernandez; Karl V Clemons; Marife Martinez
Journal: Antimicrob Agents Chemother Date: 2016-03-25 Impact factor: 5.191

In vitro antifungal activity of novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and comparison with fluconazole.

1. Efficacy of micafungin alone or in combination against systemic murine aspergillosis.

2. Large-Scale Evaluation of In Vitro Amphotericin B, Triazole, and Echinocandin Activity against Coccidioides Species from U.S. Institutions.

3. Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis.

4. Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens.

5. Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.

6. Efficacy of ravuconazole in treatment of mucosal candidosis in SCID mice.

7. Efficacy of posaconazole in a murine model of central nervous system aspergillosis.

8. Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations.

9. Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection.

10. Effect of Media Modified To Mimic Cystic Fibrosis Sputum on the Susceptibility of Aspergillus fumigatus, and the Frequency of Resistance at One Center.