Literature DB >> 12654692

Efficacy of micafungin alone or in combination against systemic murine aspergillosis.

Javier Capilla Luque1, Karl V Clemons, David A Stevens.   

Abstract

We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.

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Year:  2003        PMID： 12654692      PMCID： PMC152509          DOI： 10.1128/AAC.47.4.1452-1455.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

Review 1.  New targets and delivery systems for antifungal therapy.

Authors:  T J Walsh; M A Viviani; E Arathoon; C Chiou; M Ghannoum; A H Groll; F C Odds
Journal:  Med Mycol       Date:  2000       Impact factor: 4.076

Review 2.  Hitting a new target with echinocandins. Why chase something else?

Authors:  J R Graybill
Journal:  Curr Opin Investig Drugs       Date:  2001-04

3.  Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis.

Authors:  K V Clemons; G Grunig; R A Sobel; L F Mirels; D M Rennick; D A Stevens
Journal:  Clin Exp Immunol       Date:  2000-11       Impact factor: 4.330

Review 4.  [Invasive fungal infections. Epidemiology and new therapies].

Authors:  F Granier
Journal:  Presse Med       Date:  2000-12-02       Impact factor: 1.228

5.  Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of pulmonary aspergillosis.

Authors:  S Matsumoto; Y Wakai; T Nakai; K Hatano; T Ushitani; F Ikeda; S Tawara; T Goto; F Matsumoto; S Kuwahara
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

6.  Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens.

Authors:  D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

7.  In vitro antifungal activity of a novel lipopeptide antifungal agent, FK463, against various fungal pathogens.

Authors:  K Uchida; Y Nishiyama; N Yokota; H Yamaguchi
Journal:  J Antibiot (Tokyo)       Date:  2000-10       Impact factor: 2.649

8.  In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide.

Authors:  H Mikamo; Y Sato; T Tamaya
Journal:  J Antimicrob Chemother       Date:  2000-09       Impact factor: 5.790

9.  Efficacy of FK463, a (1,3)-beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice.

Authors:  S Maesaki; M A Hossain; Y Miyazaki; K Tomono; T Tashiro; S Kohno
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

Review 10.  Update on antifungals targeted to the cell wall: focus on beta-1,3-glucan synthase inhibitors.

Authors:  N H Georgopapadakou
Journal:  Expert Opin Investig Drugs       Date:  2001-02       Impact factor: 6.206
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  31 in total

Review 1.  Combination antifungal therapy.

Authors:  Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191

2.  Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.

Authors:  David A Stevens; Masayuki Ichinomiya; Yukako Koshi; Hiroyuki Horiuchi
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

3.  Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.

Authors:  Carly G Dennis; William R Greco; Yseult Brun; Richard Youn; Harry K Slocum; Ralph J Bernacki; Russell Lewis; Nathan Wiederhold; Steven M Holland; Ruta Petraitiene; Thomas J Walsh; Brahm H Segal
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

4.  Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis.

Authors:  Karl V Clemons; Marife Espiritu; Rachana Parmar; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

5.  Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin.

Authors:  Jon A Olson; Jill P Adler-Moore; P J Smith; Richard T Proffitt
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

Review 6.  Host immune defense against Aspergillus fumigatus: insight from experimental systemic (disseminated) infection.

Authors:  I Mirkov; S Stosic-Grujicic; M Kataranovski
Journal:  Immunol Res       Date:  2012-04       Impact factor: 2.829

7.  In vitro activities of voriconazole in combination with three other antifungal agents against Candida glabrata.

Authors:  Francesco Barchiesi; Elisabetta Spreghini; Monia Maracci; Annette W Fothergill; Isabella Baldassarri; Michael G Rinaldi; Giorgio Scalise
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

Review 8.  Micafungin.

Authors:  Blair Jarvis; David P Figgitt; Lesley J Scott
Journal:  Drugs       Date:  2004       Impact factor: 9.546

9.  Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes.

Authors:  Guojian Liao; Jine Li; Lei Li; Haihua Yang; Yuqing Tian; Huarong Tan
Journal:  Microb Cell Fact       Date:  2009-11-23       Impact factor: 5.328

10.  Fungal echinocandin resistance.

Authors:  Louise A Walker; Neil A R Gow; Carol A Munro
Journal:  Fungal Genet Biol       Date:  2009-09-19       Impact factor: 3.495
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