BACKGROUND: This was a study of the relation of clinicopathological factors to prognosis in 25 patients who had ampullary carcinoma resected. METHODS: The 5-year survival rate was six of the 25 patients. The presence of microperineural invasion was sought and related to outcome. RESULTS: Factors relating to prognosis included tumour gross appearance, diameter, pancreatic invasion and microperineural invasion. The 5-year survival rate of 14 patients with microperineural invasion was 3, significantly worse than the 7 in 11 without invasion (P = 0.002, univariate analysis). By multivariate analysis, microperineural invasion was the most important prognostic factor (P = 0.02). Type of tumour recurrence was similar to that in pancreatic carcinoma. CONCLUSION: Pancreaticoduodenectomy, rather than local resection, is the procedure of choice in patients with ampullary carcinoma.
BACKGROUND: This was a study of the relation of clinicopathological factors to prognosis in 25 patients who had ampullary carcinoma resected. METHODS: The 5-year survival rate was six of the 25 patients. The presence of microperineural invasion was sought and related to outcome. RESULTS: Factors relating to prognosis included tumour gross appearance, diameter, pancreatic invasion and microperineural invasion. The 5-year survival rate of 14 patients with microperineural invasion was 3, significantly worse than the 7 in 11 without invasion (P = 0.002, univariate analysis). By multivariate analysis, microperineural invasion was the most important prognostic factor (P = 0.02). Type of tumour recurrence was similar to that in pancreatic carcinoma. CONCLUSION: Pancreaticoduodenectomy, rather than local resection, is the procedure of choice in patients with ampullary carcinoma.
Authors: John W C Chen; Mayank Bhandari; David S Astill; Thomas G Wilson; Lilian Kow; Mark Brooke-Smith; James Toouli; Robert T A Padbury Journal: HPB (Oxford) Date: 2010-03 Impact factor: 3.647
Authors: Ioannis Hatzaras; Nathaniel George; Peter Muscarella; W Scott Melvin; E Christopher Ellison; Mark Bloomston Journal: Ann Surg Oncol Date: 2010-01-28 Impact factor: 5.344