Literature DB >> 9360615

Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.

M Ritzau1, S Heinze, K Dornberger, A Berg, W Fleck, B Schlegel, A Härtl, U Gräfe.   

Abstract

Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.

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Year:  1997        PMID： 9360615     DOI： 10.7164/antibiotics.50.722

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  The peptaibol antibiotic zervamicin displays neurotropic activity.

Authors:  T V Ovchinnikova; A N Murashev
Journal:  Dokl Biochem Biophys       Date:  2007 May-Jun       Impact factor: 0.788

2.  Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy.

Authors:  Evgeniy S Salnikov; Herdis Friedrich; Xing Li; Philippe Bertani; Siegmund Reissmann; Christian Hertweck; Joe D J O'Neil; Jan Raap; Burkhard Bechinger
Journal:  Biophys J       Date:  2009-01       Impact factor: 4.033

3.  Exploring the membrane mechanism of the bioactive peptaibol ampullosporin a using lipid monolayers and supported biomimetic membranes.

Authors:  Marguerita Eid; Sonia Rippa; Sabine Castano; Bernard Desbat; Joël Chopineau; Claire Rossi; Laure Béven
Journal:  J Biophys       Date:  2011-02-17

4.  Rare Glutamic Acid Methyl Ester Peptaibols from Sepedonium ampullosporum Damon KSH 534 Exhibit Promising Antifungal and Anticancer Activity.

Authors:  Yen T H Lam; Manuel G Ricardo; Robert Rennert; Andrej Frolov; Andrea Porzel; Wolfgang Brandt; Pauline Stark; Bernhard Westermann; Norbert Arnold
Journal:  Int J Mol Sci       Date:  2021-11-24       Impact factor: 5.923

5.  14-Residue peptaibol velutibol A from Trichoderma velutinum: its structural and cytotoxic evaluation.

Authors:  Varun Pratap Singh; Anup Singh Pathania; Manoj Kushwaha; Samsher Singh; Vandana Sharma; Fayaz A Malik; Inshad A Khan; Anil Kumar; Deepika Singh; Ram A Vishwakarma
Journal:  RSC Adv       Date:  2020-08-24       Impact factor: 4.036
  5 in total

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