Literature DB >> 9357513

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.

S M Bromidge1, M Duckworth, I T Forbes, P Ham, F D King, K M Thewlis, F E Blaney, C B Naylor, T P Blackburn, G A Kennett, M D Wood, S E Clarke.   

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Year:  1997        PMID： 9357513     DOI： 10.1021/jm970424c

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  17 in total

Review 1.  Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.

Authors:  Clint E Canal; Drake Morgan
Journal:  Drug Test Anal       Date:  2012-04-19       Impact factor: 3.345

Review 2.  A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.

Authors:  Jose M Palacios; Angel Pazos; Daniel Hoyer
Journal:  Psychopharmacology (Berl)       Date:  2017-03-07       Impact factor: 4.530

3.  Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction.

Authors:  Ana Minatti; Stephen L Buchwald
Journal:  Org Lett       Date:  2008-06-04       Impact factor: 6.005

4.  Evidence for 5-HT2B and 5-HT7 receptor-mediated relaxation in pulmonary arteries of weaned pigs.

Authors:  S Jähnichen; E Glusa; H H Pertz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-12-04       Impact factor: 3.000

5.  The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists.

Authors:  Paul J Fletcher; Judy Sinyard; Guy A Higgins
Journal:  Psychopharmacology (Berl)       Date:  2006-07-11       Impact factor: 4.530

6.  5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.

Authors:  Jennifer L Harmon; Lauren P Wills; Caitlin E McOmish; Elena Y Demireva; Jay A Gingrich; Craig C Beeson; Rick G Schnellmann
Journal:  J Pharmacol Exp Ther       Date:  2016-01-19       Impact factor: 4.030

7.  Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.

Authors:  Bradley P Morgan; Alexander Muci; Pu-Ping Lu; Xiangping Qian; Todd Tochimoto; Whitney W Smith; Marc Garard; Erica Kraynack; Scott Collibee; Ion Suehiro; Adam Tomasi; S Corey Valdez; Wenyue Wang; Hong Jiang; James Hartman; Hector M Rodriguez; Raja Kawas; Sheila Sylvester; Kathleen A Elias; Guillermo Godinez; Kenneth Lee; Robert Anderson; Sandra Sueoka; Donghong Xu; Zhengping Wang; Nebojsa Djordjevic; Fady I Malik; David J Morgans
Journal:  ACS Med Chem Lett       Date:  2010-08-20       Impact factor: 4.345

8.  Influence of the 5-HT(2C) receptor antagonist SB242,084 on behaviour produced by the 5-HT(2) agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine.

Authors:  G A Higgins; A M Ouagazzal; A J Grottick
Journal:  Br J Pharmacol       Date:  2001-06       Impact factor: 8.739

9.  Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice.

Authors:  Caleb J Browne; Xiaodong Ji; Guy A Higgins; Paul J Fletcher; Colin Harvey-Lewis
Journal:  Neuropsychopharmacology       Date:  2017-06-13       Impact factor: 7.853

10.  Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice.

Authors:  Neil E Rowland; Erica M Crump; Nancy Nguyen; Kimberly Robertson; Zhuming Sun; Raymond G Booth
Journal:  Pharmacol Biochem Behav       Date:  2008-07-19       Impact factor: 3.533
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