Literature DB >> 18522394

Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction.

Ana Minatti1, Stephen L Buchwald.   

Abstract

A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.

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Year:  2008        PMID： 18522394      PMCID： PMC2489202          DOI： 10.1021/ol8008792

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  29 in total

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  7 in total

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