Literature DB >> 9357009

Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons.

T Moriguchi1, H Matsuura, Y Kodera, Y Itakura, H Katsuki, H Saito, N Nishiyama.   

Abstract

Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.

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Year:  1997        PMID： 9357009     DOI： 10.1023/a:1021946210399

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  12 in total

1.  Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model.

Authors:  T Moriguchi; H Saito; N Nishiyama
Journal:  Clin Exp Pharmacol Physiol       Date:  1997 Mar-Apr       Impact factor: 2.557

2.  Effects of recombinant human basic fibroblast growth factor and its modified protein CS23 on survival of primary cultured neurons from various regions of fetal rat brain.

Authors:  K Abe; M Takayanagi; H Saito
Journal:  Jpn J Pharmacol       Date:  1990-06

3.  Divergent trophic actions of glioma conditioned media on cultured rat hippocampal neurons.

Authors:  S Okuda; H Saito; H Katsuki
Journal:  Biol Pharm Bull       Date:  1994-05       Impact factor: 2.233

4.  A comparison of neurotrophic effects of epidermal growth factor and basic fibroblast growth factor in primary cultured neurons from various regions of fetal rat brain.

Authors:  K Abe; M Takayanagi; H Saito
Journal:  Jpn J Pharmacol       Date:  1990-09

5.  Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis.

Authors:  Y Y Yeh; S M Yeh
Journal:  Lipids       Date:  1994-03       Impact factor: 1.880

6.  Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse.

Authors:  T Moriguchi; H Saito; N Nishiyama
Journal:  Biol Pharm Bull       Date:  1996-02       Impact factor: 2.233

7.  Antioxidant and radical scavenging effects of aged garlic extract and its constituents.

Authors:  J Imai; N Ide; S Nagae; T Moriguchi; H Matsuura; Y Itakura
Journal:  Planta Med       Date:  1994-10       Impact factor: 3.352

8.  Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture.

Authors:  S G Sundaram; J A Milner
Journal:  Cancer Lett       Date:  1993-10-15       Impact factor: 8.679

9.  Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.

Authors:  H Sumiyoshi; M J Wargovich
Journal:  Cancer Res       Date:  1990-08-15       Impact factor: 12.701

10.  Monoclonal antibodies against heparin-binding growth factor II/basic fibroblast growth factor that block its biological activity: invalidity of the antibodies for tumor angiogenesis.

Authors:  K Matsuzaki; Y Yoshitake; Y Matuo; H Sasaki; K Nishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205
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  8 in total

1.  S-allylcysteine Improves Streptozotocin-Induced Alterations of Blood Glucose, Liver Cytochrome P450 2E1, Plasma Antioxidant System, and Adipocytes Hormones in Diabetic Rats.

Authors:  Ganapathy Saravanan; Ponnusamy Ponmurugan
Journal:  Int J Endocrinol Metab       Date:  2013-10-01

2.  Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney.

Authors:  V Manoj Kumar; A K Henley; C J Nelson; O Indumati; Y Prabhakara Rao; S Rajanna; B Rajanna
Journal:  Environ Sci Pollut Res Int       Date:  2016-10-26       Impact factor: 4.223

3.  Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine.

Authors:  Diana Elinos-Calderón; Yolanda Robledo-Arratia; Verónica Pérez-De La Cruz; Perla D Maldonado; Sonia Galván-Arzate; José Pedraza-Chaverrí; Abel Santamaría
Journal:  J Neural Transm (Vienna)       Date:  2009-10-29       Impact factor: 3.575

Review 4.  The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection.

Authors:  Ana L Colín-González; Ricardo A Santana; Carlos A Silva-Islas; Maria E Chánez-Cárdenas; Abel Santamaría; Perla D Maldonado
Journal:  Oxid Med Cell Longev       Date:  2012-05-17       Impact factor: 6.543

5.  Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf.

Authors:  Takahiro Ogawa; Yukihiro Kodera; Dai Hirata; T Keith Blackwell; Masaki Mizunuma
Journal:  Sci Rep       Date:  2016-02-22       Impact factor: 4.379

6.  Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract.

Authors:  Masakazu Hashimoto; Tsuyoshi Nakai; Teruaki Masutani; Keiko Unno; Yukihiro Akao
Journal:  Nutrients       Date:  2020-06-19       Impact factor: 5.717

7.  Antioxidant and hypolipidemic potential of aged garlic extract and its constituent, s-allyl cysteine, in rats.

Authors:  Syed Mohammed Basheeruddin Asdaq
Journal:  Evid Based Complement Alternat Med       Date:  2015-03-31       Impact factor: 2.629

Review 8.  Neuroprotective mechanisms of S-allyl-L-cysteine in neurological disease.

Authors:  Yasuhiro Kosuge
Journal:  Exp Ther Med       Date:  2019-12-27       Impact factor: 2.447
  8 in total

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