Literature DB >> 9343247

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.

N Kato1, K H Lan, S K Ono-Nita, Y Shiratori, M Omata.   

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

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Year:  1997        PMID： 9343247      PMCID： PMC192353          DOI： 10.1128/JVI.71.11.8856-8859.1997

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

Review 1.  Adenovirus promoters and E1A transactivation.

Authors:  A J Berk
Journal:  Annu Rev Genet       Date:  1986       Impact factor: 16.830

2.  Deletion analysis of GAL4 defines two transcriptional activating segments.

Authors:  J Ma; M Ptashne
Journal:  Cell       Date:  1987-03-13       Impact factor: 41.582

3.  Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins.

Authors:  E Castle; U Leidner; T Nowak; G Wengler; G Wengler
Journal:  Virology       Date:  1986-02       Impact factor: 3.616

4.  A new class of yeast transcriptional activators.

Authors:  J Ma; M Ptashne
Journal:  Cell       Date:  1987-10-09       Impact factor: 41.582

5.  Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription.

Authors:  M E Campbell; J W Palfreyman; C M Preston
Journal:  J Mol Biol       Date:  1984-11-25       Impact factor: 5.469

6.  Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.

Authors:  C M Rice; E M Lenches; S R Eddy; S J Shin; R L Sheets; J H Strauss
Journal:  Science       Date:  1985-08-23       Impact factor: 47.728

7.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.

Authors:  E Schwarz; U K Freese; L Gissmann; W Mayer; B Roggenbuck; A Stremlau; H zur Hausen
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

8.  Complete nucleotide sequence of the Japanese encephalitis virus genome RNA.

Authors:  H Sumiyoshi; C Mori; I Fuke; K Morita; S Kuhara; J Kondou; Y Kikuchi; H Nagamatu; A Igarashi
Journal:  Virology       Date:  1987-12       Impact factor: 3.616

9.  Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.

Authors:  H Nakabayashi; K Taketa; K Miyano; T Yamane; J Sato
Journal:  Cancer Res       Date:  1982-09       Impact factor: 12.701

10.  Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

Authors:  M Seiki; J Inoue; T Takeda; M Yoshida
Journal:  EMBO J       Date:  1986-03       Impact factor: 11.598
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  28 in total

1.  Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population.

Authors:  Xiao-Ming Zhou; Paul Ks Chan; John S Tam
Journal:  World J Gastroenterol       Date:  2011-12-28       Impact factor: 5.742

2.  Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy.

Authors:  J Nousbaum; S J Polyak; S C Ray; D G Sullivan; A M Larson; R L Carithers; D R Gretch
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

3.  Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance.

Authors:  Ming-Yi Chen; Zhi-Qiang Huang; Le-Zhen Chen; Ya-Bing Gao; Rui-Yun Peng; De-Wen Wang
Journal:  World J Gastroenterol       Date:  2000-12       Impact factor: 5.742

4.  Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.

Authors:  Yuka Takahama; Hirofumi Uto; Shuji Kanmura; Makoto Oketani; Akio Ido; Kazunori Kusumoto; Satoru Hasuike; Kenji Nagata; Katsuhiro Hayashi; Sherri Stuver; Akihiko Okayama; Hirohito Tsubouchi
Journal:  J Gastroenterol       Date:  2008-12-24       Impact factor: 7.527

5.  NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.

Authors:  S L Tan; H Nakao; Y He; S Vijaysri; P Neddermann; B L Jacobs; B J Mayer; M G Katze
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

6.  Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1.

Authors:  Ishtiaq Qadri; Mieko Iwahashi; Juan M Capasso; Matthew W Hopken; Sonia Flores; Jerome Schaack; Francis R Simon
Journal:  Biochem J       Date:  2004-03-15       Impact factor: 3.857

7.  HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding.

Authors:  Guo-Zhong Gong; Yong-Fang Jiang; Yan He; Li-Ying Lai; Ying-Hua Zhu; Xian-Shi Su
Journal:  World J Gastroenterol       Date:  2004-08-01       Impact factor: 5.742

8.  TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.

Authors:  Dinesh Babu Uthaya Kumar; Chia-Lin Chen; Jian-Chang Liu; Douglas E Feldman; Linda S Sher; Samuel French; Joseph DiNorcia; Samuel W French; Bita V Naini; Sunhawit Junrungsee; Vatche Garen Agopian; Ali Zarrinpar; Keigo Machida
Journal:  Gastroenterology       Date:  2015-11-12       Impact factor: 22.682

9.  Calcium-dependent calpain proteases are implicated in processing of the hepatitis C virus NS5A protein.

Authors:  M Kalamvoki; P Mavromara
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

10.  Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog.

Authors:  Keigo Machida; Hidekazu Tsukamoto; Hasmik Mkrtchyan; Lewei Duan; Alla Dynnyk; Helene Minyi Liu; Kinji Asahina; Sugantha Govindarajan; Ratna Ray; Jing-Hsiung James Ou; Ekihiro Seki; Raymond Deshaies; Kensuke Miyake; Michael M-C Lai
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-26       Impact factor: 11.205
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