Literature DB >> 9333163

DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.

D Zhang1, X Yang, J Berry, C Shen, G McClarty, R C Brunham.   

Abstract

The efficacy of DNA vaccination for prevention of Chlamydia trachomatis infection was studied using the murine model of pneumonia induced by the mouse pneumonitis (MoPn) isolate of C. trachomatis. Intramuscular DNA immunization with two chlamydial genes, one that encodes the major outer-membrane protein (MOMP) and one that encodes a cytoplasmic enzyme (cytosine triphosphate [CTP] synthetase) were tested. The MOMP DNA vaccine but not the CTP synthetase DNA vaccine generated significant delayed-type hypersensitivity and serum antibodies to MoPn elementary bodies and reduced the peak growth of MoPn by >100-fold following lung challenge infection. MOMP DNA immunization suggests a new approach to vaccine development for prevention of human chlamydial infection.

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Year:  1997        PMID： 9333163     DOI： 10.1086/516545

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  28 in total

1.  Expression of genes encoding Th1 cell-activating cytokines and lymphoid homing chemokines by chlamydia-pulsed dendritic cells correlates with protective immunizing efficacy.

Authors:  J H Shaw; V R Grund; L Durling; H D Caldwell
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

Review 2.  Chlamydial infection in sheep: immune control versus fetal pathology.

Authors:  G Entrican; D Buxton; D Longbottom
Journal:  J R Soc Med       Date:  2001-06       Impact factor: 5.344

Review 3.  Immunity to murine chlamydial genital infection.

Authors:  Richard P Morrison; Harlan D Caldwell
Journal:  Infect Immun       Date:  2002-06       Impact factor: 3.441

4.  T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.

Authors:  X Yang; R Brunham
Journal:  Can J Infect Dis       Date:  1998-03

5.  Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production.

Authors:  Ashlesh K Murthy; James P Chambers; Patricia A Meier; Guangming Zhong; Bernard P Arulanandam
Journal:  Infect Immun       Date:  2006-11-21       Impact factor: 3.441

6.  Sequence polymorphism, predicted secondary structures, and surface-exposed conformational epitopes of Campylobacter major outer membrane protein.

Authors:  Q Zhang; J C Meitzler; S Huang; T Morishita
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

7.  Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteria.

Authors:  Sukumar Pal; Ellena M Peterson; Luis M de la Maza
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

8.  Immunization with Chlamydia psittaci plasmid-encoded protein CPSIT_p7 induces partial protective immunity against chlamydia lung infection in mice.

Authors:  Yuan Tan; Yumeng Li; Yang Zhang; Jian Yu; Yating Wen; Chuan Wang; Man Xu; Qian Chen; Chunxue Lu; Yimou Wu
Journal:  Immunol Res       Date:  2018-08       Impact factor: 2.829

9.  Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein.

Authors:  D Vanrompay; E Cox; G Volckaert; B Goddeeris
Journal:  Clin Exp Immunol       Date:  1999-10       Impact factor: 4.330

10.  Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein can elicit a protective immune response against a genital challenge.

Authors:  S Pal; I Theodor; E M Peterson; L M de la Maza
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441
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