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Literature DB >> 9333072

Quinolone susceptibility of norA-disrupted Staphylococcus aureus.

H Yamada¹, S Kurose-Hamada, Y Fukuda, J Mitsuyama, M Takahata, S Minami, Y Watanabe, H Narita.

Abstract

The MIC of norfloxacin for the norA-disrupted mutant termed RDN1, obtained from quinolone-susceptible Staphylococcus aureus RN4220, was eightfold lower than that for RN4220. The increase in susceptibility was related to an increase of drug accumulation by RDN1. These results indicate that NorA plays an important role in the susceptibility of quinolone-susceptible S. aureus to selected quinolones.

Entities: Chemical Species

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Year: 1997 PMID： 9333072 PMCID： PMC164117

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

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Authors: K Ubukata; N Itoh-Yamashita; M Konno
Journal: Antimicrob Agents Chemother Date: 1989-09 Impact factor: 5.191

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Journal: N Engl J Med Date: 1991-02-07 Impact factor: 91.245

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Journal: Ann Intern Med Date: 1991-03-01 Impact factor: 25.391

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Authors: K Ubukata; R Nonoguchi; M Matsuhashi; M D Song; M Konno
Journal: Antimicrob Agents Chemother Date: 1989-09 Impact factor: 5.191

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Authors: H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal: J Bacteriol Date: 1990-12 Impact factor: 3.490

6. The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.

Authors: A A Neyfakh
Journal: Antimicrob Agents Chemother Date: 1992-02 Impact factor: 5.191

7. Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus.

Authors: T Takenouchi; F Tabata; Y Iwata; H Hanzawa; M Sugawara; S Ohya
Journal: Antimicrob Agents Chemother Date: 1996-08 Impact factor: 5.191

8. Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes.

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Journal: J Bacteriol Date: 1983-02 Impact factor: 3.490

9. Routes of quinolone permeation in Escherichia coli.

Authors: J S Chapman; N H Georgopapadakou
Journal: Antimicrob Agents Chemother Date: 1988-04 Impact factor: 5.191

10. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.

Authors: G W Kaatz; S M Seo; C A Ruble
Journal: J Infect Dis Date: 1991-05 Impact factor: 5.226

16 in total

Review 1. Molecular properties of bacterial multidrug transporters.

Authors: M Putman; H W van Veen; W N Konings
Journal: Microbiol Mol Biol Rev Date: 2000-12 Impact factor: 11.056

2. Ers controls glycerol metabolism in Enterococcus faecalis.

Authors: Eliette Riboulet-Bisson; Axel Hartke; Yanick Auffray; Jean-Christophe Giard
Journal: Curr Microbiol Date: 2008-11-06 Impact factor: 2.188

3. Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus.

Authors: G W Kaatz; S M Seo; L O'Brien; M Wahiduzzaman; T J Foster
Journal: Antimicrob Agents Chemother Date: 2000-05 Impact factor: 5.191

4. Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

Authors: P N Markham; E Westhaus; K Klyachko; M E Johnson; A A Neyfakh
Journal: Antimicrob Agents Chemother Date: 1999-10 Impact factor: 5.191

Review 5. Regulation of bacterial drug export systems.

Authors: Steve Grkovic; Melissa H Brown; Ronald A Skurray
Journal: Microbiol Mol Biol Rev Date: 2002-12 Impact factor: 11.056

6. A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.

Authors: Jack R Davison; Katheryn M Lohith; Xiaoning Wang; Kostyantyn Bobyk; Sivakoteswara R Mandadapu; Su-Lin Lee; Regina Cencic; Justin Nelson; Scott Simpkins; Karen M Frank; Jerry Pelletier; Chad L Myers; Jeff Piotrowski; Harold E Smith; Carole A Bewley
Journal: Antimicrob Agents Chemother Date: 2017-05-24 Impact factor: 5.191

7. DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.

Authors: X S Pan; L M Fisher
Journal: Antimicrob Agents Chemother Date: 1998-11 Impact factor: 5.191

8. Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus.

Authors: H Fukuda; S Hori; K Hiramatsu
Journal: Antimicrob Agents Chemother Date: 1998-08 Impact factor: 5.191

9. Characterization of the Ers regulon of Enterococcus faecalis.

Authors: Eliette Riboulet-Bisson; Maurizio Sanguinetti; Aurélie Budin-Verneuil; Yanick Auffray; Axel Hartke; Jean-Christophe Giard
Journal: Infect Immun Date: 2008-04-21 Impact factor: 3.441

10. Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.

Authors: P C Hsieh; S A Siegel; B Rogers; D Davis; K Lewis
Journal: Proc Natl Acad Sci U S A Date: 1998-06-09 Impact factor: 11.205