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Literature DB >> 932533

Malondialdehyde formation as an indicator of prostaglandin production by human platelets.

Abstract

The formation of malondialdehyde, a metabolite of prostaglandin endoperoxides, has been studied in platelet-rich plasma. Small amounts were produced in response to ADP, epinephrine, or collagen and larger amounts in response to thrombin. Arachidonic acid induced platelets to produce large amounts of malondialdehyde. Malondialdehyde formation by platelets was prevented by aspirin or indomethacin. The measurement of malondialdehyde in platelet-rich plasma may be used as an indicator of platelet prostaglandin synthesis, and is simpler than the measurement of prostaglandins.

Entities: Chemical Gene Species

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Year: 1976 PMID： 932533

Source DB: PubMed Journal: J Lab Clin Med ISSN： 0022-2143

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Cited

35 in total

1. The effect of platelet activating factor antagonist (BN 52021) on cerulein-induced acute pancreatitis with reference to oxygen radicals.

Authors: A Dabrowski; A Gabryelewicz; L Chyczewski
Journal: Int J Pancreatol Date: 1991-01

2. Anion channel blockers cause apparent inhibition of exocytosis by reacting with agonist or secretory product, not with cell.

Authors: J G Vostal; D M Reid; C E Jones; N R Shulman
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

Malondialdehyde formation as an indicator of prostaglandin production by human platelets.

1. The effect of platelet activating factor antagonist (BN 52021) on cerulein-induced acute pancreatitis with reference to oxygen radicals.

2. Anion channel blockers cause apparent inhibition of exocytosis by reacting with agonist or secretory product, not with cell.

Review 3. The oxidative stress theory of disease: levels of evidence and epistemological aspects.

4. Interrelations of platelet aggregation and secretion.

5. Relationship between platelet cyclooxygenase pathway and plasma malondialdehyde-like material.

6. Prostanoid mediated effects of centchroman, a non-steroidal oral contraceptive.

7. Ascorbate and malondialdehyde in stroke patients.

8. Long term treatment with theophylline increases malonyl dialdehyde plasma concentrations.

9. Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase.

10. The role of platelet aggregation and release in fragment D-induced pulmonary dysfunction.