Literature DB >> 743261

Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase.

R M McMillan, D E MacIntyre, A Booth, J L Gordon.   

Abstract

Imidazole and compound L8027 (selective inhibitors of thromboxane synthase) produced parallel inhibition of malonaldehyde and thromboxane B2 secretion induced by collagen or thrombin in gel-filtered suspensions of human platelets. Comparing the effects of these inhibitors and aspirin on secretion of granule constituents indicated that platelet degranulation depends mainly on thromboxane production; prostaglandin endoperoxides contributed little.

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Year:  1978        PMID： 743261      PMCID： PMC1186270          DOI： 10.1042/bj1760595

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  Simple, sensitive fluorimetric assay for malondialdehyde production by blood platelets.

Authors:  R M McMillan; D E MacIntyre; J L Gordon
Journal:  Thromb Res       Date:  1977-09       Impact factor: 3.944

3.  Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandins.

Authors:  D E MacIntyre; E W Salzman; J L Gordon
Journal:  Biochem J       Date:  1978-09-15       Impact factor: 3.857

4.  Selective inhibition of thromboxane A2 biosynthesis in blood platelets.

Authors:  R J Gryglewski; A Zmuda; R Korbut; E Krecioch; K Bieron
Journal:  Nature       Date:  1977-06-16       Impact factor: 49.962

5.  Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase.

Authors:  U Diczfalusy; P Falardeau; S Hammarström
Journal:  FEBS Lett       Date:  1977-12-15       Impact factor: 4.124

6.  A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors.

Authors:  F A Fitzpatrick; R R Gorman
Journal:  Biochim Biophys Acta       Date:  1978-03-01

7.  Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.

Authors:  P Needleman; A Raz; J A Ferrendelli; M Minkes
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

8.  The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs.

Authors:  G J Blackwell; W G Duncombe; R J Flower; M F Parsons; J R Vane
Journal:  Br J Pharmacol       Date:  1977-02       Impact factor: 8.739

9.  Malondialdehyde production by platelets during secondary aggregation.

Authors:  D E MacFarlane; S Gardner; C Lipson; D C Mills
Journal:  Thromb Haemost       Date:  1977-12-15       Impact factor: 5.249

10.  A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reaction.

Authors:  J L Gordon; A H Drummond
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857
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  1 in total

1.  Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid.

Authors:  J P Brammer; M H Maguire
Journal:  Br J Pharmacol       Date:  1984-05       Impact factor: 8.739
  1 in total

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