Literature DB >> 9324963

Fluorometric assay for the determination of DNA-DNA cross-links utilizing Hoechst 33258 at neutral pH values.

P G Penketh1, K Shyam, A C Sartorelli.   

Abstract

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Year:  1997        PMID： 9324963     DOI： 10.1006/abio.1997.9996

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


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  10 in total

1.  pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.

Authors:  Philip G Penketh; Richard A Finch; Rachel Sauro; Raymond P Baumann; Elena S Ratner; Krishnamurthy Shyam
Journal:  Chem Biol Drug Des       Date:  2017-07-17       Impact factor: 2.817

2.  1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: an anticancer agent targeting hypoxic cells.

Authors:  Helen A Seow; Philip G Penketh; Krishnamurthy Shyam; Sara Rockwell; Alan C Sartorelli
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-17       Impact factor: 11.205

3.  A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.

Authors:  Philip G Penketh; Krishnamurthy Shyam; Raymond P Baumann; Kimiko Ishiguro; Eric V Patridge; Rui Zhu; Alan C Sartorelli
Journal:  Chem Biol Drug Des       Date:  2012-05-23       Impact factor: 2.817

4.  Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA.

Authors:  M F Belcourt; P G Penketh; W F Hodnick; D A Johnson; D H Sherman; S Rockwell; A C Sartorelli
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

5.  When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments.

Authors:  Philip G Penketh; Krishnamurthy Shyam; Raymond P Baumann; Rui Zhu; Kimiko Ishiguro; Alan C Sartorelli; Elena S Ratner
Journal:  Anal Biochem       Date:  2016-05-14       Impact factor: 3.365

6.  Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.

Authors:  Philip G Penketh; Raymond P Baumann; Kimiko Ishiguro; Krishnamurthy Shyam; Helen A Seow; Alan C Sartorelli
Journal:  Leuk Res       Date:  2008-05-13       Impact factor: 3.156

7.  Modification of cellular DNA by synthetic aziridinomitosenes.

Authors:  Chris M Mallory; Ryan P Carfi; SangPhil Moon; Kenneth A Cornell; Don L Warner
Journal:  Bioorg Med Chem       Date:  2015-10-21       Impact factor: 3.641

8.  Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W.

Authors:  Philip G Penketh; Krishnamurthy Shyam; Rui Zhu; Raymond P Baumann; Kimiko Ishiguro; Alan C Sartorelli
Journal:  Chem Res Toxicol       Date:  2014-03-24       Impact factor: 3.739

9.  Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine.

Authors:  Philip G Penketh; Eric Patridge; Krishnamurthy Shyam; Raymond P Baumann; Rui Zhu; Kimiko Ishiguro; Alan C Sartorelli
Journal:  Chem Res Toxicol       Date:  2014-07-17       Impact factor: 3.739

10.  A novel gene delivery composite system based on biodegradable folate-poly (ester amine) polymer and thermosensitive hydrogel for sustained gene release.

Authors:  Yi Yang; Hang Zhao; YanPeng Jia; QingFa Guo; Ying Qu; Jing Su; XiaoLing Lu; YongXiang Zhao; ZhiYong Qian
Journal:  Sci Rep       Date:  2016-02-17       Impact factor: 4.379
  10 in total

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