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Literature DB >> 18479747

Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.

Philip G Penketh¹, Raymond P Baumann, Kimiko Ishiguro, Krishnamurthy Shyam, Helen A Seow, Alan C Sartorelli.

Abstract

Cloretazine [1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine; VNP40101M; 101M] is a relatively new prodrug with activity in elderly acute myelogenous leukemia (AML) patients. Its therapeutic action is due largely to the production of 1-(3-cytosinyl),2-(1-guanyl)ethane cross-links (G-C ethane cross-links) in DNA. The numbers of cross-links produced in three experimental leukemia lines (L1210, U937 and HL-60) were fewer than 10 per genome at their respective LC50 concentrations. Only 1 in approximately 20,000 90CE molecules produces a cross-link in the AGT (O6-alkylguanine-DNA alkyltransferase) negative L1210 and U937 cell lines and 1 in 400,000 in the AGT positive HL-60 cell line.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2008 PMID： 18479747 PMCID： PMC2888535 DOI： 10.1016/j.leukres.2008.03.005

Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156

32 in total

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