Literature DB >> 931800

Biotransformation, a new approach to aminoglycoside biosynthesis: II. Gentamicin.

R T Testa, B C Tilley.   

Abstract

Utilizing a paromamine-producing mutant of Micromonospora purpurea blocked in the production of gentamicin, bioconversion of various minor gentamicin components into the gentamicin C complex was demonstrated. The compounds tested were structurally related to the gentamicin C's and are found as minor components in the gentamicin fermentation. Based upon the bioconversions detected, a branched pathway for the biosynthesis of the gentamicin C components is proposed.

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Year:  1976        PMID： 931800     DOI： 10.7164/antibiotics.29.140

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Biotransformation of sisomicin to gentamicin C2b.

Authors:  B K Lee; J V Bailey; R G Condon; J A Marquez; G H Wagman; M J Weinstein
Journal:  Antimicrob Agents Chemother       Date:  1977-09       Impact factor: 5.191

2.  The role of the pseudo-disaccharide neamine as an intermediate in the biosynthesis of neomycin.

Authors:  C J Pearce; J E Barnett; C Anthony; M Akhtar; S D Gero
Journal:  Biochem J       Date:  1976-12-01       Impact factor: 3.857

3.  GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

Authors:  Hak Joong Kim; Reid M McCarty; Yasushi Ogasawara; Yung-nan Liu; Steven O Mansoorabadi; Jake LeVieux; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2013-05-21       Impact factor: 15.419

4.  Biosynthetic pathway leading to gentamicin C2b.

Authors:  B K Lee; T L Nagabhushan; R G Condon; G Shimonaski; M G Kalyanpur; M Patel; J A Waitz
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

5.  Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set.

Authors:  Je Won Park; Jay Sung Joong Hong; Niranjan Parajuli; Won Seok Jung; Sung Ryeol Park; Si-Kyu Lim; Jae Kyung Sohng; Yeo Joon Yoon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-12       Impact factor: 11.205

6.  Delineating the biosynthesis of gentamicin x2, the common precursor of the gentamicin C antibiotic complex.

Authors:  Chuan Huang; Fanglu Huang; Eileen Moison; Junhong Guo; Xinyun Jian; Xiaobo Duan; Zixin Deng; Peter F Leadlay; Yuhui Sun
Journal:  Chem Biol       Date:  2015-01-29

7.  Assembly of a novel biosynthetic pathway for gentamicin B production in Micromonospora echinospora.

Authors:  Xianpu Ni; Zhenpeng Sun; Yawen Gu; Hao Cui; Huanzhang Xia
Journal:  Microb Cell Fact       Date:  2016-01-05       Impact factor: 5.328

8.  Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS.

Authors:  Yingying Chang; Baozhong Chai; Yunkun Ding; Min He; Linghui Zheng; Yun Teng; Zixin Deng; Yi Yu; Tiangang Liu
Journal:  Metab Eng Commun       Date:  2019-07-24

9.  Specificity and promiscuity at the branch point in gentamicin biosynthesis.

Authors:  Junhong Guo; Fanglu Huang; Chuan Huang; Xiaobo Duan; Xinyun Jian; Finian Leeper; Zixin Deng; Peter F Leadlay; Yuhui Sun
Journal:  Chem Biol       Date:  2014-04-17

10.  Complete reconstitution of the diverse pathways of gentamicin B biosynthesis.

Authors:  Yeon Hee Ban; Myoung Chong Song; Jae-Yeon Hwang; Hea-Lyung Shin; Hak Joong Kim; Seung Kon Hong; Na Joon Lee; Je Won Park; Sun-Shin Cha; Hung-Wen Liu; Yeo Joon Yoon
Journal:  Nat Chem Biol       Date:  2019-01-14       Impact factor: 15.040
  10 in total

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