Literature DB >> 9314047

Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate.

C H Hoyle1, J Pintor, J Gualix, M T Miras-Portugal.   

Abstract

Diinosine pentaphosphate (Ip5I) antagonized contractions, mediated via P2X receptors, evoked by diadenosine pentaphosphate (Ap5A) and ATP in the guinea-pig isolated vas deferens with pA2 values of 6.4 +/- 0.17 (10 d.f.) and 6.5 +/- 0.10 (10 d.f.), respectively. Ip5I (30 microM) did not affect contractile responses evoked by noradrenaline. Ip5I (up to 100 microM) did not antagonize P2Y receptors in the guinea-pig taenia coli, nor P1 or P2 receptors in the guinea-pig left atrium.

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Year:  1997        PMID： 9314047     DOI： 10.1016/s0014-2999(97)01129-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

Review 1.  Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system.

Authors:  Vera Jankowski; Markus van der Giet; Harald Mischak; Michael Morgan; Walter Zidek; Joachim Jankowski
Journal:  Br J Pharmacol       Date:  2009-06-25       Impact factor: 8.739

2.  Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors.

Authors:  B F King; M Liu; J Pintor; J Gualix; M T Miras-Portugal; G Burnstock
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

3.  P2X(1) receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo.

Authors:  David A Osmond; Edward W Inscho
Journal:  Am J Physiol Renal Physiol       Date:  2010-03-24

4.  Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors.

Authors:  Sean G Brown; Yong-Chul Kim; Soon-Ai Kim; Kenneth A Jacobson; Geoffrey Burnstock; Brian F King
Journal:  Drug Dev Res       Date:  2001-10-18       Impact factor: 4.360
  4 in total

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