Literature DB >> 931373

Radiometric determination of the concentration of amphotericin B in body fluids.

R L Hopfer, D Gröschel.   

Abstract

A new assay was developed to determine the concentration of amphotericin B in body fluids. The Bactec radiometric system was used to measure CO(2) production by a test strain, Candida albicans MDA 448, in the presence of amphotericin B. After 5-h incubation, drug concentrations as low as 0.2 mug/ml could be detected. The results are comparable to those of the commonly used agar diffusion assay with Paecilomyces varioti.

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Year:  1977        PMID： 931373      PMCID： PMC430013          DOI： 10.1128/AAC.12.6.733

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

Review 1.  Analysis and assay of polyene antifungal antibiotics. A review.

Authors:  A H Thomas
Journal:  Analyst       Date:  1976-05       Impact factor: 4.616

2.  Fungistatic activity, uptake and incorporation of 5-fluorocytosine in Candida albicans, as influenced by pyrimidines and purines. I. Reversal experiments.

Authors:  A Polak; H J Scholer
Journal:  Pathol Microbiol (Basel)       Date:  1973

3.  A semi-quantitative spectrophotometric assay for amphotericin B in blood.

Authors:  P A Herd; H F Martin
Journal:  Clin Biochem       Date:  1974-12       Impact factor: 3.281

4.  Chromatographic analysis of heptaene macrolide antibiotics.

Authors:  D H Calam
Journal:  J Chromatogr Sci       Date:  1974-10       Impact factor: 1.618

5.  A pharmacologic guide to the clinical use of amphotericin B.

Authors:  D D Bindschadler; J E Bennett
Journal:  J Infect Dis       Date:  1969-10       Impact factor: 5.226

6.  Rubidium release: a rapid and sensitive assay for amphotericin B.

Authors:  R E Drazin; R I Lehrer
Journal:  J Infect Dis       Date:  1976-09       Impact factor: 5.226

7.  Bioassay for hamycin and amphotericin B in serum and other biological fluids.

Authors:  S Shadomy; J A McCay; S I Schwartz
Journal:  Appl Microbiol       Date:  1969-04

8.  Amphotericin B susceptibility testing of yeasts with a bactec radiometric system.

Authors:  R L Hopfer; D Gröschel
Journal:  Antimicrob Agents Chemother       Date:  1977-02       Impact factor: 5.191
  8 in total
  2 in total

Review 1.  Clinical pharmacokinetics of systemic antifungal drugs.

Authors:  T K Daneshmend; D W Warnock
Journal:  Clin Pharmacokinet       Date:  1983 Jan-Feb       Impact factor: 6.447

2.  Sensitive high-pressure liquid chromatographic assay for amphotericin B which incorporates an internal standard.

Authors:  G G Granich; G S Kobayashi; D J Krogstad
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191
  2 in total

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