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Literature DB >> 9312037

The role of U5 snRNP in pre-mRNA splicing.

Abstract

The current model for the function of the U5 small nuclear ribonucleoprotein particle (snRNP) in the spliceosome proposes that U5 carries binding sites for the 5' and 3' exons, allowing the spliceosome to 'tether' the 5' exon intermediate produced by the first catalytic step and align it with the 3' exon for the second step. Functional analysis of U5 snRNA in cis-spliceosomes has provided support for this model, and data from nematode and trypanosome splicing systems suggest that U5 or a U5-like snRNA performs a similar role in trans-splicing.

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Year: 1997 PMID： 9312037 PMCID： PMC1170210 DOI： 10.1093/emboj/16.19.5797

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

24 in total

Review 1. Dynamic RNA-RNA interactions in the spliceosome.

Authors: H D Madhani; C Guthrie
Journal: Annu Rev Genet Date: 1994 Impact factor: 16.830

Review 2. RNA-RNA interactions in the spliceosome: unraveling the ties that bind.

Authors: T W Nilsen
Journal: Cell Date: 1994-07-15 Impact factor: 41.582

Review 3. Structure and activities of group II introns.

Authors: F Michel; J L Ferat
Journal: Annu Rev Biochem Date: 1995 Impact factor: 23.643

4. Extraordinary sequence conservation of the PRP8 splicing factor.

Authors: P E Hodges; S P Jackson; J D Brown; J D Beggs
Journal: Yeast Date: 1995-04-15 Impact factor: 3.239

5. The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome.

Authors: J L Reyes; P Kois; B B Konforti; M M Konarska
Journal: RNA Date: 1996-03 Impact factor: 4.942

6. Functionally redundant interactions between U2 and U6 spliceosomal snRNAs.

Authors: D J Field; J D Friesen
Journal: Genes Dev Date: 1996-02-15 Impact factor: 11.361

7. Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs.

Authors: B Laggerbauer; J Lauber; R Lührmann
Journal: Nucleic Acids Res Date: 1996-03-01 Impact factor: 16.971

8. snRNA interactions at 5' and 3' splice sites monitored by photoactivated crosslinking in yeast spliceosomes.

Authors: A J Newman; S Teigelkamp; J D Beggs
Journal: RNA Date: 1995-11 Impact factor: 4.942

9. A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.

Authors: J S Sun; J L Manley
Journal: Genes Dev Date: 1995-04-01 Impact factor: 11.361

10. The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases.

Authors: J Lauber; P Fabrizio; S Teigelkamp; W S Lane; E Hartmann; R Luhrmann
Journal: EMBO J Date: 1996-08-01 Impact factor: 11.598

39 in total

1. A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation.

Authors: T Tuschl; P A Sharp; D P Bartel
Journal: RNA Date: 2001-01 Impact factor: 4.942

2. ATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site.

Authors: R K Alvi; M Lund; R T Okeefe
Journal: RNA Date: 2001-07 Impact factor: 4.942

3. PSF and p54nrb bind a conserved stem in U5 snRNA.

Authors: Rui Peng; Billy T Dye; Ismael Pérez; Daron C Barnard; Amanda B Thompson; James G Patton
Journal: RNA Date: 2002-10 Impact factor: 4.942

4. Analysis of the conformational energy landscape of human snRNA with a metric based on tree representation of RNA structures.

Authors: Junji Kitagawa; Yasuhiro Futamura; Kenji Yamamoto
Journal: Nucleic Acids Res Date: 2003-04-01 Impact factor: 16.971

8. Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly.

Authors: Mikko J Frilander; Xiaojuan Meng
Journal: Mol Cell Biol Date: 2005-06 Impact factor: 4.272

9. Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.

Authors: Dagmar Bacíková; David S Horowitz
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272

10. Temperature-sensitive splicing in the floral homeotic mutant apetala3-1.

Authors: R W Sablowski; E M Meyerowitz
Journal: Plant Cell Date: 1998-09 Impact factor: 11.277