Literature DB >> 9309765

The current status of antiparasite chemotherapy.

S L Croft1.   

Abstract

Currently used antiparasitic drugs, including benzimidazoles, nitroimidazoles, avermectins, polyene ionophores, hydroxynaphthoquinones and sesquiterpene lactones, were identified through the empirical route to drug discovery. The modern rational approach to drug design is focused upon the structure and function of biochemical and molecular targets. The requisite pharmacological properties for new anti-parasite drugs should not be ignored in this process.

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Year:  1997        PMID： 9309765

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  19 in total

Review 1.  Clinical and experimental advances in treatment of visceral leishmaniasis.

Authors:  H W Murray
Journal:  Antimicrob Agents Chemother       Date:  2001-08       Impact factor: 5.191

2.  Antitrypanosomal activities of proteasome inhibitors.

Authors:  Njinkeng Joseph Nkemngu; Joseph Nkemgu-Njinkeng; Vera Rosenkranz; Michael Wink; Dietmar Steverding
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

3.  Trypanocidal and leishmanicidal properties of substitution-containing chalcones.

Authors:  Fabiane Lunardi; Michel Guzela; Andrea T Rodrigues; Rogério Corrêa; Iriane Eger-Mangrich; Mário Steindel; Edmundo C Grisard; Jamil Assreuy; João B Calixto; Adair R S Santos
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

4.  (-)-Hinokinin-loaded poly(D,-lactide-co-glycolide) microparticles for Chagas disease.

Authors:  Juliana Saraiva; Ana Amélia Moreira Lira; Viviane Rodrigues Esperandim; Daniele da Silva Ferreira; Antônio Sérgio Ferraudo; Jairo Kenupp Bastos; Márcio Luís Andrade E Silva; Cristiane Masetto de Gaitani; Sérgio de Albuquerque; Juliana Maldonado Marchetti
Journal:  Parasitol Res       Date:  2010-01-28       Impact factor: 2.289

5.  New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

Authors:  Ludovic Gros; Victor Manuel Castillo-Acosta; Carmen Jiménez Jiménez; Marco Sealey-Cardona; Sofia Vargas; Antonio Manuel Estévez; Vanessa Yardley; Lauren Rattray; Simon L Croft; Luis M Ruiz-Perez; Julio A Urbina; Ian H Gilbert; Dolores González-Pacanowska
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

6.  Lipophilic antifolate trimetrexate is a potent inhibitor of Trypanosoma cruzi: prospect for chemotherapy of Chagas' disease.

Authors:  Olga Senkovich; Vandanajay Bhatia; Nisha Garg; Debasish Chattopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

7.  Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Authors:  J C Bressi; C L Verlinde; A M Aronov; M L Shaw; S S Shin; L N Nguyen; S Suresh; F S Buckner; W C Van Voorhis; I D Kuntz; W G Hol; M H Gelb
Journal:  J Med Chem       Date:  2001-06-21       Impact factor: 7.446

8.  In vitro and in vivo activity of lignan lactones derivatives against Trypanosoma cruzi.

Authors:  Juliana Saraiva; Celeste Vega; Mirian Rolon; Rosangela da Silva; Márcio Luis Andrade E Silva; Paulo Marcos Donate; Jairo Kenupp Bastos; Alícia Gomez-Barrio; Sérgio de Albuquerque
Journal:  Parasitol Res       Date:  2006-10-12       Impact factor: 2.289

9.  Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains.

Authors:  Yong-Soon Hwang; Eung-Soo Kim; Sándor Biró; Cha-Yong Choi
Journal:  Appl Environ Microbiol       Date:  2003-02       Impact factor: 4.792

10.  In vitro and in vivo activities of trybizine hydrochloride against various pathogenic trypanosome species.

Authors:  R Kaminsky; R Brun
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191
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