| Literature DB >> 9306970 |
H J Delecluse1, T Marafioti, M Hummel, F Dallenbach, I Anagnostopoulos, H Stein.
Abstract
Hodgkin's disease (HD) is associated with the Epstein-Barr virus (EBV) in approximately half of cases. This is a report of a case of nodular sclerosing HD of the B-cell type that was associated with EBV in the initial manifestation, but was found to be EBV-negative in the relapse of the tumour. Both tumours displayed similar clinical, pathological, and immunohistochemical features. This finding implies that in a given individual EBV can be lost from malignant tumours and therefore shows that the EBV infection is not required to maintain neoplastic growth of HD tumour cells.Entities:
Mesh:
Substances:
Year: 1997 PMID: 9306970 DOI: 10.1002/(SICI)1096-9896(199708)182:4<475::AID-PATH878>3.0.CO;2-6
Source DB: PubMed Journal: J Pathol ISSN: 0022-3417 Impact factor: 7.996