Literature DB >> 9306652

Merits of secretion of heterologous proteins from industrial microorganisms.

W J Quax1.   

Abstract

The heterologous expression of proteins is without doubt one of the most fascinating applications of the recombinant DNA technique. Despite clear successes many attempts to produce a certain protein in a heterologous host cell have met with technical difficulties. Secretion from cells has been used as a solution to overcome the intracellular formation of inactive protein. Microorganisms with a history of use in the fermentation industry exhibit clear advantages over the frequently used Escherichia coli as host cells for secreted products. Interleukin-3, chymosin and phytase are examples of commercial products that are produced efficiently with the aid of industrial microorganisms.

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Year:  1997        PMID： 9306652     DOI： 10.1007/BF02898715

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.629


  8 in total

1.  Hybrid genes expressing fusion peptides. A strategy for bacterial production of recombinant human interleukin-3 with a defined NH2-terminus.

Authors:  F Kricek; C Ruf; H Aschauer; P Stuchlik; C Graf; J M Seifert; F J Werner; G Ehn
Journal:  Ann N Y Acad Sci       Date:  1991-12-27       Impact factor: 5.691

2.  Human insulin from recombinant DNA technology.

Authors:  I S Johnson
Journal:  Science       Date:  1983-02-11       Impact factor: 47.728

3.  Structure and mechanism of formation of recombinant-derived chymosin C.

Authors:  D E Danley; K F Geoghegan
Journal:  J Biol Chem       Date:  1988-07-15       Impact factor: 5.157

4.  Effects of recombinant human interleukin-3 in patients with relapsed small-cell lung cancer treated with chemotherapy: a dose-finding study.

Authors:  P E Postmus; J A Gietema; O Damsma; B Biesma; P C Limburg; E Vellenga; E G de Vries
Journal:  J Clin Oncol       Date:  1992-07       Impact factor: 44.544

5.  The effect of supplementary Aspergillus niger phytase in diets for pigs on concentration and apparent digestibility of dry matter, total phosphorus, and phytic acid in different sections of the alimentary tract.

Authors:  A W Jongbloed; Z Mroz; P A Kemme
Journal:  J Anim Sci       Date:  1992-04       Impact factor: 3.159

6.  Kluyveromyces as a host for heterologous gene expression: expression and secretion of prochymosin.

Authors:  J A van den Berg; K J van der Laken; A J van Ooyen; T C Renniers; K Rietveld; A Schaap; A J Brake; R J Bishop; K Schultz; D Moyer
Journal:  Biotechnology (N Y)       Date:  1990-02

7.  Production of human interleukin-3 using industrial microorganisms.

Authors:  R W van Leen; J G Bakhuis; R F van Beckhoven; H Burger; L C Dorssers; R W Hommes; P J Lemson; B Noordam; N L Persoon; G Wagemaker
Journal:  Biotechnology (N Y)       Date:  1991-01

8.  Improved production of chymosin in Aspergillus by expression as a glucoamylase-chymosin fusion.

Authors:  M Ward; L J Wilson; K H Kodama; M W Rey; R M Berka
Journal:  Biotechnology (N Y)       Date:  1990-05
  8 in total
  6 in total

1.  Role of the cell wall microenvironment in expression of a heterologous SpaP-S1 fusion protein by Streptococcus gordonii.

Authors:  Elisabeth Davis; Dustin Kennedy; Scott A Halperin; Song F Lee
Journal:  Appl Environ Microbiol       Date:  2010-12-30       Impact factor: 4.792

Review 2.  Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome.

Authors:  H Tjalsma; A Bolhuis; J D Jongbloed; S Bron; J M van Dijl
Journal:  Microbiol Mol Biol Rev       Date:  2000-09       Impact factor: 11.056

3.  Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol-xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum.

Authors:  Sandra Scheele; Dan Oertel; Johannes Bongaerts; Stefan Evers; Hendrik Hellmuth; Karl-Heinz Maurer; Michael Bott; Roland Freudl
Journal:  Microb Biotechnol       Date:  2012-11-20       Impact factor: 5.813

Review 4.  Signal peptides for recombinant protein secretion in bacterial expression systems.

Authors:  Roland Freudl
Journal:  Microb Cell Fact       Date:  2018-03-29       Impact factor: 5.328

5.  Establishment of a functional system for recombinant production of secreted proteins at 50 °C in the thermophilic Bacillus methanolicus.

Authors:  Marta Irla; Eivind B Drejer; Trygve Brautaset; Sigrid Hakvåg
Journal:  Microb Cell Fact       Date:  2020-07-28       Impact factor: 5.328

6.  A secretion biosensor for monitoring Sec-dependent protein export in Corynebacterium glutamicum.

Authors:  Sarah Jurischka; Astrid Bida; Doris Dohmen-Olma; Britta Kleine; Janko Potzkei; Stephan Binder; Georg Schaumann; Patrick J Bakkes; Roland Freudl
Journal:  Microb Cell Fact       Date:  2020-01-21       Impact factor: 5.328
  6 in total

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