Literature DB >> 9305354

Frequency and significance of antinuclear antibodies in multiple sclerosis.

R C Collard1, R P Koehler, D H Mattson.   

Abstract

In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.

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Year:  1997        PMID： 9305354     DOI： 10.1212/wnl.49.3.857

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  13 in total

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