Literature DB >> 9302994

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.

M Geyer, C Herrmann, S Wohlgemuth, A Wittinghofer, H R Kalbitzer.   

Abstract

The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD.

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Year:  1997        PMID： 9302994     DOI： 10.1038/nsb0997-694

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  23 in total

1.  Sequential NMR assignment of the RAS-binding domain of Byr2.

Authors:  F Huber; W Gronwald; S Wohlgemuth; C Herrmann; M Geyer; A Wittinghofer; H R Kalbitzer
Journal:  J Biomol NMR       Date:  2000-04       Impact factor: 2.835

2.  Conformational switch and role of phosphorylation in PAK activation.

Authors:  G Buchwald; E Hostinova; M G Rudolph; A Kraemer; A Sickmann; H E Meyer; K Scheffzek; A Wittinghofer
Journal:  Mol Cell Biol       Date:  2001-08       Impact factor: 4.272

3.  Overcoming the problems associated with poor spectra quality of the protein kinase Byr2 using residual dipolar couplings.

Authors:  W Gronwald; E Brunner; F Huber; M Wenzler; C Herrmann; H R Kalbitzer
Journal:  Protein Sci       Date:  2001-06       Impact factor: 6.725

4.  Automated assignment of NOESY NMR spectra using a knowledge based method (KNOWNOE).

Authors:  Wolfram Gronwald; Sherif Moussa; Ralph Elsner; Astrid Jung; Bernhard Ganslmeier; Jochen Trenner; Werner Kremer; Klaus-Peter Neidig; Hans Robert Kalbitzer
Journal:  J Biomol NMR       Date:  2002-08       Impact factor: 2.835

5.  AUREMOL-RFAC-3D, combination of R-factors and their use for automated quality assessment of protein solution structures.

Authors:  Wolfram Gronwald; Konrad Brunner; Renate Kirchhöfer; Jochen Trenner; Klaus-Peter Neidig; Hans Robert Kalbitzer
Journal:  J Biomol NMR       Date:  2006-11-29       Impact factor: 2.835

6.  Dynamic properties of the Ras switch I region and its importance for binding to effectors.

Authors:  M Spoerner; C Herrmann; I R Vetter; H R Kalbitzer; A Wittinghofer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

7.  Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions.

Authors:  Frank H Schumann; Hubert Riepl; Till Maurer; Wolfram Gronwald; Klaus-Peter Neidig; Hans Robert Kalbitzer
Journal:  J Biomol NMR       Date:  2007-10-23       Impact factor: 2.835

8.  Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.

Authors:  Kousuke Matsumoto; Fumi Shima; Shin Muraoka; Mitsugu Araki; Lizhi Hu; Yuichi Ijiri; Rina Hirai; Jingling Liao; Takashi Yoshioka; Takashi Kumasaka; Masaki Yamamoto; Atsuo Tamura; Tohru Kataoka
Journal:  J Biol Chem       Date:  2011-03-09       Impact factor: 5.157

9.  Protein-protein recognition: an experimental and computational study of the R89K mutation in Raf and its effect on Ras binding.

Authors:  J Zeng; M Fridman; H Maruta; H R Treutlein; T Simonson
Journal:  Protein Sci       Date:  1999-01       Impact factor: 6.725

Review 10.  Why nature really chose phosphate.

Authors:  Shina C L Kamerlin; Pankaz K Sharma; Ram B Prasad; Arieh Warshel
Journal:  Q Rev Biophys       Date:  2013-01-15       Impact factor: 5.318
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