Literature DB >> 9302992

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.

M R Ahmadian, P Stege, K Scheffzek, A Wittinghofer.   

Abstract

RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.

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Year:  1997        PMID： 9302992     DOI： 10.1038/nsb0997-686

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  128 in total

1.  Characterization of the hinges of the effector loop in the reaction pathway of the activation of ras-proteins. Kinetics of binding of beryllium trifluoride to V29G and I36G mutants of Ha-ras-p21.

Authors:  S Kuppens; J F Díaz; Y Engelborghs
Journal:  Protein Sci       Date:  1999-09       Impact factor: 6.725

Review 2.  Transport into and out of the nucleus.

Authors:  I G Macara
Journal:  Microbiol Mol Biol Rev       Date:  2001-12       Impact factor: 11.056

3.  Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.

Authors:  A Rak; R Fedorov; K Alexandrov; S Albert; R S Goody; D Gallwitz; A J Scheidig
Journal:  EMBO J       Date:  2000-10-02       Impact factor: 11.598

4.  Induced nucleotide specificity in a GTPase.

Authors:  Shu-ou Shan; Peter Walter
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-27       Impact factor: 11.205

5.  Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases.

Authors:  Adolfo Zurita; Yinghao Zhang; Lee Pedersen; Tom Darden; Lutz Birnbaumer
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-10       Impact factor: 11.205

6.  Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?

Authors:  Michael J Seewald; Astrid Kraemer; Marian Farkasovsky; Carolin Körner; Alfred Wittinghofer; Ingrid R Vetter
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

7.  Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42.

Authors:  Sarah F Elliott; George Allen; David J Timson
Journal:  World J Biol Chem       Date:  2012-03-26

8.  The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

Authors:  Elisabeth Kravets; Daniel Degrandi; Stefanie Weidtkamp-Peters; Britta Ries; Carolin Konermann; Suren Felekyan; Julia M Dargazanli; Gerrit J K Praefcke; Claus A M Seidel; Lutz Schmitt; Sander H J Smits; Klaus Pfeffer
Journal:  J Biol Chem       Date:  2012-06-22       Impact factor: 5.157

9.  Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.

Authors:  Phi Luong; Lisa N Kinch; Chad A Brautigam; Nick V Grishin; Diana R Tomchick; Kim Orth
Journal:  J Biol Chem       Date:  2010-04-21       Impact factor: 5.157

Review 10.  Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins.

Authors:  Brenda A Wilson; Mengfei Ho
Journal:  Future Microbiol       Date:  2010-08       Impact factor: 3.165
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