Literature DB >> 11302837

Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14.

F Nicoletti1, R Di Marco, P Sacerdote, P Meroni, K Mangano, C Edwards, A Bartorelli, K Bendtzen, A Panerai.   

Abstract

Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.

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Year:  2001        PMID： 11302837      PMCID： PMC90515          DOI： 10.1128/AAC.45.5.1591-1594.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases.

Authors:  A E Panerai; P Sacerdote; M Bianchi; F Nicoletti; B Manfredi; L Gaspani; A Bartorelli; F Ceciliani; S Ronchi
Journal:  Ann N Y Acad Sci       Date:  1999-06-22       Impact factor: 5.691

Review 2.  Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity.

Authors:  K Bendtzen
Journal:  Immunol Lett       Date:  1988-11       Impact factor: 3.685

3.  Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

Authors:  A Ashkenazi; S A Marsters; D J Capon; S M Chamow; I S Figari; D Pennica; D V Goeddel; M A Palladino; D H Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

4.  A new kinetic single-stage Limulus amoebocyte lysate method for the detection of endotoxin in water and plasma.

Authors:  K I Dunér
Journal:  J Biochem Biophys Methods       Date:  1993-05

5.  Interleukin-1 receptor antagonist reduces mortality from endotoxin shock.

Authors:  K Ohlsson; P Björk; M Bergenfeldt; R Hageman; R C Thompson
Journal:  Nature       Date:  1990-12-06       Impact factor: 49.962

6.  Characterization, purification and cDNA cloning of a rat perchloric-acid-soluble 23-kDa protein present only in liver and kidney.

Authors:  F Levy-Favatier; L Cuisset; B Nedelec; L Tichonicky; J Kruh; M Delpech
Journal:  Eur J Biochem       Date:  1993-03-15

7.  The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells.

Authors:  H Tang; K Mignon-Godefroy; P L Meroni; G Garotta; J Charreire; F Nicoletti
Journal:  Eur J Immunol       Date:  1993-01       Impact factor: 5.532

8.  Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

Authors:  C Gérard; C Bruyns; A Marchant; D Abramowicz; P Vandenabeele; A Delvaux; W Fiers; M Goldman; T Velu
Journal:  J Exp Med       Date:  1993-02-01       Impact factor: 14.307

9.  Interleukin 10 protects mice from lethal endotoxemia.

Authors:  M Howard; T Muchamuel; S Andrade; S Menon
Journal:  J Exp Med       Date:  1993-04-01       Impact factor: 14.307

10.  A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.

Authors:  H R Alexander; G M Doherty; C M Buresh; D J Venzon; J A Norton
Journal:  J Exp Med       Date:  1991-04-01       Impact factor: 14.307
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