Literature DB >> 9299412

The peroxisome proliferator-activated receptor alpha (PPAR alpha) regulates the plasma thiobarbituric acid-reactive substance (TBARS) level.

I Inoue1, S Noji, M Z Shen, K Takahashi, S Katayama.   

Abstract

We investigated whether liver expression of the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene is related to the plasma thiobarbituric acid-reactive substance (TBARS) level, as well as to plasma cholesterol (TC) level and plasma triglyceride (TG) level in rats fed a high fat chow containing a variety of fatty acids. Only the plasma TBARS level showed a significant negative correlation with the liver PPAR alpha mRNA level (TC, R = 0.001, p = 0.9967; TG, R = 0.248, p = 0.1276; TBARS, R = 0.439, p = 0.0046). Although further studies are needed to clarify whether the increase of the liver PPAR alpha mRNA level confers a reduction in plasma TBARS levels, it is likely that PPAR alpha activity plays a regulatory role in the pathogenesis of hyperlipidemia and atherosclerosis.

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Year:  1997        PMID： 9299412     DOI： 10.1006/bbrc.1997.7196

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

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Journal:  Mol Cell Biochem       Date:  2001-01       Impact factor: 3.396

4.  Short-term effect of bezafibrate on the expression of adiponectin mRNA in the adipose tissues: a study in spontaneously type 2 diabetic rats with visceral obesity.

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  6 in total

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