Literature DB >> 9284931

Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.

F Shimizu1, T Katagiri, M Suzuki, T K Watanabe, S Okuno, Y Kuga, M Nagata, T Fujiwara, Y Nakamura, E Takahashi.   

Abstract

A full-length cDNA homologous to RAB7, a member of the RAB-related GTP-binding protein subfamily, was isolated from a human placenta cDNA library. This cDNA, designated RAB7L1, has an open reading frame of 609 nucleotides encoding 203 amino acids. Northern analysis showed that the mRNA is ubiquitously expressed in human tissues, although signal intensities were different among the various organs examined. This gene was located on chromosome band 1q32 by fluorescence in situ hybridization.

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Year:  1997        PMID: 9284931     DOI: 10.1159/000134591

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN: 0301-0171


  11 in total

1.  The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1.

Authors:  Aurore Keutgens; Kateryna Shostak; Pierre Close; Xin Zhang; Benoît Hennuy; Marie Aussems; Jean-Paul Chapelle; Patrick Viatour; André Gothot; Marianne Fillet; Alain Chariot
Journal:  Mol Cell Biol       Date:  2010-06-14       Impact factor: 4.272

2.  Association of three candidate genetic variants in RAB7L1/NUCKS1, MCCC1 and STK39 with sporadic Parkinson's disease in Han Chinese.

Authors:  Ling Wang; Lan Cheng; Zhong-Jiao Lu; Xiao-Yi Sun; Jun-Ying Li; Rong Peng
Journal:  J Neural Transm (Vienna)       Date:  2016-02-25       Impact factor: 3.575

Review 3.  The genetics of Parkinson disease.

Authors:  Lynn M Bekris; Ignacio F Mata; Cyrus P Zabetian
Journal:  J Geriatr Psychiatry Neurol       Date:  2010-10-11       Impact factor: 2.680

4.  A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions.

Authors:  Yuko Hirota; Yoshitaka Tanaka
Journal:  Cell Mol Life Sci       Date:  2009-07-11       Impact factor: 9.261

5.  RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.

Authors:  Xiaoxing Tan; Yuchong Wei; Jie Cao; Degang Wu; Niansheng Lai; Ruming Deng; Haiying Li; Haitao Shen; Ya Peng; Xiang Li; Gang Chen
Journal:  J Mol Neurosci       Date:  2020-07-20       Impact factor: 3.444

6.  RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

Authors:  David A MacLeod; Herve Rhinn; Tomoki Kuwahara; Ari Zolin; Gilbert Di Paolo; Brian D McCabe; Brian D MacCabe; Karen S Marder; Lawrence S Honig; Lorraine N Clark; Scott A Small; Asa Abeliovich
Journal:  Neuron       Date:  2013-02-06       Impact factor: 17.173

7.  Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.

Authors:  Wataru Satake; Yuko Nakabayashi; Ikuko Mizuta; Yushi Hirota; Chiyomi Ito; Michiaki Kubo; Takahisa Kawaguchi; Tatsuhiko Tsunoda; Masahiko Watanabe; Atsushi Takeda; Hiroyuki Tomiyama; Kenji Nakashima; Kazuko Hasegawa; Fumiya Obata; Takeo Yoshikawa; Hideshi Kawakami; Saburo Sakoda; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Yusuke Nakamura; Tatsushi Toda
Journal:  Nat Genet       Date:  2009-11-15       Impact factor: 38.330

8.  Methylation quantitative trait locus analysis of chronic postsurgical pain uncovers epigenetic mediators of genetic risk.

Authors:  Vidya Chidambaran; Xue Zhang; Valentina Pilipenko; Xiaoting Chen; Benjamin Wronowski; Kristie Geisler; Lisa J Martin; Artem Barski; Matthew T Weirauch; Hong Ji
Journal:  Epigenomics       Date:  2021-04-06       Impact factor: 4.778

9.  A two-stage meta-analysis identifies several new loci for Parkinson's disease.

Authors: 
Journal:  PLoS Genet       Date:  2011-06-30       Impact factor: 5.917

10.  Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.

Authors:  Mark W Dodson; Lok K Leung; Mohiddin Lone; Michael A Lizzio; Ming Guo
Journal:  Dis Model Mech       Date:  2014-10-02       Impact factor: 5.758

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