Literature DB >> 9277143

An assay for the quantitation of Photofrin in tissues and fluids.

D A Bellnier1, W R Greco, J C Parsons, A R Oseroff, A Kuebler, T J Dougherty.   

Abstract

A method for determining the concentration of Photofrin in tissues and biological fluids was developed. The procedure is based on the dissolution of biological material with Solvable, a commercially available tissue solubilizer, followed by porphyrin-specific fluorescence detection and measurement. It was found necessary to use a quadratic standard curve for the estimation of unknown Photofrin concentrations. While this method is limited to compounds that are stable in strong base, it has the advantages of being sensitive, rapid and low cost.

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Year:  1997        PMID: 9277143     DOI: 10.1111/j.1751-1097.1997.tb08649.x

Source DB:  PubMed          Journal:  Photochem Photobiol        ISSN: 0031-8655            Impact factor:   3.421


  7 in total

1.  Tumor vascular microenvironment determines responsiveness to photodynamic therapy.

Authors:  Amanda L Maas; Shirron L Carter; E Paul Wileyto; Joann Miller; Min Yuan; Guoqiang Yu; Amy C Durham; Theresa M Busch
Journal:  Cancer Res       Date:  2012-02-28       Impact factor: 12.701

2.  Light delivery over extended time periods enhances the effectiveness of photodynamic therapy.

Authors:  Mukund Seshadri; David A Bellnier; Lurine A Vaughan; Joseph A Spernyak; Richard Mazurchuk; Thomas H Foster; Barbara W Henderson
Journal:  Clin Cancer Res       Date:  2008-05-01       Impact factor: 12.531

3.  IL-6 potentiates tumor resistance to photodynamic therapy (PDT).

Authors:  Craig M Brackett; Barbara Owczarczak; Kimberley Ramsey; Patricia G Maier; Sandra O Gollnick
Journal:  Lasers Surg Med       Date:  2011-09       Impact factor: 4.025

4.  Mechanisms in photodynamic therapy: Part three-Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction.

Authors:  Ana P Castano; Tatiana N Demidova; Michael R Hamblin
Journal:  Photodiagnosis Photodyn Ther       Date:  2005-08-10       Impact factor: 3.631

5.  Lack of effect of sex and disease state on the pharmacokinetics of porfimer sodium.

Authors:  Jean-Marie Houle; Nadine Clervoix; Stacey Bain; Jean Spénard
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

6.  Pre-clinical compartmental pharmacokinetic modeling of 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) as a photosensitizer in rat plasma by validated HPLC method.

Authors:  Kowthavarapu Venkata Krishna; Ranendra Narayana Saha; Anu Puri; Mathias Viard; Bruce A Shapiro; Sunil Kumar Dubey
Journal:  Photochem Photobiol Sci       Date:  2019-05-15       Impact factor: 3.982

7.  Reduction of tumour oxygenation during and after photodynamic therapy in vivo: effects of fluence rate.

Authors:  T M Sitnik; J A Hampton; B W Henderson
Journal:  Br J Cancer       Date:  1998-05       Impact factor: 7.640

  7 in total

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