OBJECTIVES: To clarify the autonomic dysfunctions in amyotrophic lateral sclerosis (ALS) patients, we investigated the relationship between blood pressure (BP) and pulse rate (PR), QTc interval, and coefficient of variation in the R-R interval (CVR-R) in ALS patients. MATERIALS AND METHODS: BP and PR were determined automatically every 30 min for 24 h in 6 patients with ALS and in 18 healthy age-matched volunteers. The QTc interval and CVR-R were also evaluated using an electrocardiogram. RESULTS: The relationship between BP and PR was lost in the ALS group. There was no significant difference in the QTc interval or CVR-R between the ALS and control groups. CONCLUSION: We speculate that the imbalance between BP and PR observed in the ALS group reflects a disorder in the balance between the sympathetic and parasympathetic nervous systems.
OBJECTIVES: To clarify the autonomic dysfunctions in amyotrophic lateral sclerosis (ALS) patients, we investigated the relationship between blood pressure (BP) and pulse rate (PR), QTc interval, and coefficient of variation in the R-R interval (CVR-R) in ALSpatients. MATERIALS AND METHODS: BP and PR were determined automatically every 30 min for 24 h in 6 patients with ALS and in 18 healthy age-matched volunteers. The QTc interval and CVR-R were also evaluated using an electrocardiogram. RESULTS: The relationship between BP and PR was lost in the ALS group. There was no significant difference in the QTc interval or CVR-R between the ALS and control groups. CONCLUSION: We speculate that the imbalance between BP and PR observed in the ALS group reflects a disorder in the balance between the sympathetic and parasympathetic nervous systems.
Authors: Nicole Silbernagel; Magdalena Walecki; Martin K-H Schäfer; Mirjam Kessler; Mehrnoush Zobeiri; Susanne Rinné; Aytug K Kiper; Marlene A Komadowski; Kirsty S Vowinkel; Konstantin Wemhöner; Lisa Fortmüller; Marcus Schewe; Amalia M Dolga; Jelena Scekic-Zahirovic; Lina A Matschke; Carsten Culmsee; Thomas Baukrowitz; Laurent Monassier; Nina D Ullrich; Luc Dupuis; Steffen Just; Thomas Budde; Larissa Fabritz; Niels Decher Journal: FASEB J Date: 2018-06-07 Impact factor: 5.191
Authors: Angela Rosenbohm; Benjamin Schmid; Dominik Buckert; Wolfgang Rottbauer; Jan Kassubek; Albert C Ludolph; Peter Bernhardt Journal: Front Neurol Date: 2017-09-27 Impact factor: 4.003