P L Megaw1, I G Morgan, M K Boelen. 1. Centre for Research on Ageing and Health, La Trobe University, Bendigo, Victoria, Australia. respm@redgum.bendigo.latrobe.edu.au
Abstract
PURPOSE: Dopamine (DA) is considered to be a neurotransmitter involved in light-adaptive responses in the retina and has been implicated in the control of the eye growth induced by form deprivation. Vitreal DOPAC was shown to be a good indicator of retinal dopaminergic activity. METHODS/ RESULTS: Dopaminergic activity was highest during the light; with vitreal DOPAC levels rising within 3 h of light exposure. Form deprivation attenuated dopaminergic activity, as the rise in vitreal DOPAC levels on light exposure was reduced in form-deprived eyes, compared with control eyes. CONCLUSION: The lack of sustained activation of DA release may explain the role of DA in the control of eye-growth.
PURPOSE:Dopamine (DA) is considered to be a neurotransmitter involved in light-adaptive responses in the retina and has been implicated in the control of the eye growth induced by form deprivation. Vitreal DOPAC was shown to be a good indicator of retinal dopaminergic activity. METHODS/ RESULTS: Dopaminergic activity was highest during the light; with vitreal DOPAC levels rising within 3 h of light exposure. Form deprivation attenuated dopaminergic activity, as the rise in vitreal DOPAC levels on light exposure was reduced in form-deprived eyes, compared with control eyes. CONCLUSION: The lack of sustained activation of DA release may explain the role of DA in the control of eye-growth.
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