Literature DB >> 9264246

Why are Hox genes clustered?

R S Mann1.   

Abstract

The evolutionarily conserved genomic organization of the Hox genes has been a puzzle ever since it was discovered that their order along the chromosome is similar to the order of their functional domains along the antero-posterior axis. Why has this colinearity been maintained throughout evolution? A close look at regulatory sequences from the mouse Hox clusters suggests that enhancer sharing between adjacent Hox genes may be one reason. Moreover, characterizing the activity of one of these mouse enhancers in Drosophila illustrates that despite many similarities, not all Hox clusters are built in the same way.

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Year:  1997        PMID: 9264246     DOI: 10.1002/bies.950190804

Source DB:  PubMed          Journal:  Bioessays        ISSN: 0265-9247            Impact factor:   4.345


  11 in total

1.  The ten Hox genes of the millipede Glomeris marginata.

Authors:  Ralf Janssen; Wim G M Damen
Journal:  Dev Genes Evol       Date:  2006-07-01       Impact factor: 0.900

2.  Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy.

Authors:  Scott Barolo
Journal:  Bioessays       Date:  2011-11-15       Impact factor: 4.345

3.  Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development.

Authors:  T Peters; R Dildrop; K Ausmeier; U Rüther
Journal:  Genome Res       Date:  2000-10       Impact factor: 9.043

4.  A conserved cluster of three PRD-class homeobox genes (homeobrain, rx and orthopedia) in the Cnidaria and Protostomia.

Authors:  Maureen E Mazza; Kevin Pang; Adam M Reitzel; Mark Q Martindale; John R Finnerty
Journal:  Evodevo       Date:  2010-07-05       Impact factor: 2.250

Review 5.  Spatial organization of genes as a component of regulated expression.

Authors:  Dave A Pai; David R Engelke
Journal:  Chromosoma       Date:  2009-08-30       Impact factor: 4.316

6.  Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.

Authors:  Joseph F Ryan; Maureen E Mazza; Kevin Pang; David Q Matus; Andreas D Baxevanis; Mark Q Martindale; John R Finnerty
Journal:  PLoS One       Date:  2007-01-24       Impact factor: 3.240

7.  Extensive polycistronism and antisense transcription in the mammalian Hox clusters.

Authors:  Gaëll Mainguy; Jan Koster; Joost Woltering; Hans Jansen; Antony Durston
Journal:  PLoS One       Date:  2007-04-04       Impact factor: 3.240

8.  The peach (Prunus persica L. Batsch) genome harbours 10 KNOX genes, which are differentially expressed in stem development, and the class 1 KNOPE1 regulates elongation and lignification during primary growth.

Authors:  Giulio Testone; Emiliano Condello; Ignazio Verde; Chiara Nicolodi; Emilia Caboni; Maria Teresa Dettori; Elisa Vendramin; Leonardo Bruno; Maria Beatrice Bitonti; Giovanni Mele; Donato Giannino
Journal:  J Exp Bot       Date:  2012-08-09       Impact factor: 6.992

9.  MicroRNA targets in Drosophila.

Authors:  Anton J Enright; Bino John; Ulrike Gaul; Thomas Tuschl; Chris Sander; Debora S Marks
Journal:  Genome Biol       Date:  2003-12-12       Impact factor: 13.583

10.  Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.

Authors:  Boris Novakovic; Thierry Fournier; Lynda K Harris; Joanna James; Claire T Roberts; Hannah E J Yong; Bill Kalionis; Danièle Evain-Brion; Peter R Ebeling; Euan M Wallace; Richard Saffery; Padma Murthi
Journal:  Sci Rep       Date:  2017-07-03       Impact factor: 4.379

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