| Literature DB >> 9260593 |
H Kirschke1, T Clausen, B Göhring, D Günther, E Heucke, F Laube, E Löwe, H Neef, H Papesch, S Peinze, G Plehn, U Rebmann, A Rinne, R Rüdrich, E Weber.
Abstract
Renal cell carcinoma contains significantly lower concentrations of the lysosomal cysteine proteases, cathepsins B, C, H, L and S, than does normal kidney, as shown by several methods, such as activity determination, enzyme-linked immunosorbent assay, immunoblotting and immunohistochemistry. The same low levels of enzyme activity and concentration have been determined in renal cell carcinoma metastases in the lung. Our results on the decreased concentration of cysteine peptidases at the protein level would seem to conflict with earlier results on an increased concentration of the cathepsin L mRNA in renal cell carcinoma.Entities:
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Year: 1997 PMID： 9260593 DOI： 10.1007/bf01240124
Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553