Literature DB >> 9249970

Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.

Y F Hallock1, K P Manfredi, J R Dai, J H Cardellina, R J Gulakowski, J B McMahon, M Schäffer, M Stahl, K P Gulden, G Bringmann, G François, M R Boyd.   

Abstract

New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.

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Year:  1997        PMID： 9249970     DOI： 10.1021/np9700679

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

Review 1.  Antiplasmodial natural products: an update.

Authors:  Nasir Tajuddeen; Fanie R Van Heerden
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2.  Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells.

Authors:  Blaise Kimbadi Lombe; Doris Feineis; Virima Mudogo; Reto Brun; Suresh Awale; Gerhard Bringmann
Journal:  RSC Adv       Date:  2018-01-31       Impact factor: 4.036

Review 3.  Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents.

Authors:  R Sagaya Jansi; Ameer Khusro; Paul Agastian; Ahmed Alfarhan; Naif Abdullah Al-Dhabi; Mariadhas Valan Arasu; Rajakrishnan Rajagopal; Damia Barcelo; Amal Al-Tamimi
Journal:  Sci Total Environ       Date:  2020-11-07       Impact factor: 7.963

4.  Ancistrobreveines A-D and related dehydrogenated naphthylisoquinoline alkaloids with antiproliferative activities against leukemia cells, from the West African liana Ancistrocladus abbreviatus.

Authors:  Shaimaa Fayez; Doris Feineis; Laurent Aké Assi; Ean-Jeong Seo; Thomas Efferth; Gerhard Bringmann
Journal:  RSC Adv       Date:  2019-05-20       Impact factor: 3.361

5.  Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,8'-coupled monomeric alkaloids, ikelacongolines A-D, from a Congolese Ancistrocladus liana.

Authors:  Jean-Pierre Mufusama; Doris Feineis; Virima Mudogo; Marcel Kaiser; Reto Brun; Gerhard Bringmann
Journal:  RSC Adv       Date:  2019-04-16       Impact factor: 4.036

6.  Antiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis.

Authors:  Dieudonné Tshitenge Tshitenge; Doris Feineis; Virima Mudogo; Marcel Kaiser; Reto Brun; Gerhard Bringmann
Journal:  Sci Rep       Date:  2017-07-18       Impact factor: 4.379

Review 7.  The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens.

Authors:  Amin Thawabteh; Salma Juma; Mariam Bader; Donia Karaman; Laura Scrano; Sabino A Bufo; Rafik Karaman
Journal:  Toxins (Basel)       Date:  2019-11-11       Impact factor: 4.546
  7 in total

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