Literature DB >> 9247127

The modular phosphorylation and activation of p70s6k.

N Pullen1, G Thomas.   

Abstract

The activation of p70s6k is accompanied by a complex series of phosphorylation events. In this review we propose a model of activation which divides p70s6k into four functional modules that cooperate in leading to full enzyme activity. In the light of the model, we suggest how candidate effectors of p70s6k activation might function by directing the phosphorylation of specific sites.

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Year:  1997        PMID： 9247127     DOI： 10.1016/s0014-5793(97)00323-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  139 in total

Review 1.  Multiple pathways control protein kinase C phosphorylation.

Authors:  D B Parekh; W Ziegler; P J Parker
Journal:  EMBO J       Date:  2000-02-15       Impact factor: 11.598

Review 2.  Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis.

Authors:  M P Scheid; J R Woodgett
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-01       Impact factor: 2.673

3.  Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated protein kinase.

Authors:  M Montcouquiol; J T Corwin
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

4.  Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.

Authors:  Yewseok Suh; Farrukh Afaq; Naghma Khan; Jeremy J Johnson; Fatima H Khusro; Hasan Mukhtar
Journal:  Carcinogenesis       Date:  2010-06-08       Impact factor: 4.944

5.  mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells.

Authors:  Charles A Easley; Ahmi Ben-Yehudah; Carrie J Redinger; Stacie L Oliver; Sandra T Varum; Vonya M Eisinger; Diane L Carlisle; Peter J Donovan; Gerald P Schatten
Journal:  Cell Reprogram       Date:  2010-06       Impact factor: 1.987

6.  Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: a search for biomarkers of sensitivity to treatment.

Authors:  Victoria L Bae-Jump; Chunxiao Zhou; John F Boggess; Young E Whang; Lisa Barroilhet; Paola A Gehrig
Journal:  Gynecol Oncol       Date:  2010-09-21       Impact factor: 5.482

7.  Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways.

Authors:  Qiong Liu; Jing Chen; Xu Wang; Liang Yu; Li-hong Hu; Xu Shen
Journal:  Acta Pharmacol Sin       Date:  2010-07-19       Impact factor: 6.150

8.  ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.

Authors:  M A Olayioye; D Graus-Porta; R R Beerli; J Rohrer; B Gay; N E Hynes
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

9.  S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.

Authors:  Thomas Hubert; Zilu Wu; Andrew D Chisholm; Yishi Jin
Journal:  J Neurosci       Date:  2014-01-15       Impact factor: 6.167

10.  Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1).

Authors:  Timothy J Ragan; Duncan B Ross; Malik M Keshwani; Thomas K Harris
Journal:  Protein Expr Purif       Date:  2007-10-01       Impact factor: 1.650
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