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Literature DB >> 11467455

Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis.

Abstract

Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol 3' kinase pathway plays a seminal role in cell death suppression or "survival signaling." Over the past 5 years, the molecular mechanisms by which this pathway exerts its death suppressive effects have slowly been revealed. This review summarizes the players involved, their importance in human cancer and their specific involvement in breast cancer.

Entities: Disease Species

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Year: 2001 PMID： 11467455 DOI： 10.1023/a:1009520616247

Source DB: PubMed Journal: J Mammary Gland Biol Neoplasia ISSN： 1083-3021 Impact factor: 2.673

152 in total

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11 in total

Review 1. Modular evolution of phosphorylation-based signalling systems.

Authors: Jing Jin; Tony Pawson
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2012-09-19 Impact factor: 6.237

Review 2. Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia.

Authors: Ewa M Kosciuczuk; Diana Saleiro; Leonidas C Platanias
Journal: Cytokine Date: 2016-04-16 Impact factor: 3.861

3. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.

Authors: Christina Gewinner; Zhigang C Wang; Andrea Richardson; Julie Teruya-Feldstein; Dariush Etemadmoghadam; David Bowtell; Jordi Barretina; William M Lin; Lucia Rameh; Leonardo Salmena; Pier Paolo Pandolfi; Lewis C Cantley
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4. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

Authors: Ping Yi; Qin Feng; Larbi Amazit; David M Lonard; Sophia Y Tsai; Ming-Jer Tsai; Bert W O'Malley
Journal: Mol Cell Date: 2008-02-29 Impact factor: 17.970

Review 5. The ras signaling pathway in mammary tumorigenesis and metastasis.

Authors: S Malaney; R J Daly
Journal: J Mammary Gland Biol Neoplasia Date: 2001-01 Impact factor: 2.698

6. PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.

Authors: Y Shrestha; E J Schafer; J S Boehm; S R Thomas; F He; J Du; S Wang; J Barretina; B A Weir; J J Zhao; K Polyak; T R Golub; R Beroukhim; W C Hahn
Journal: Oncogene Date: 2011-11-21 Impact factor: 9.867

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Authors: Wa Xian; Kathryn L Schwertfeger; Tracy Vargo-Gogola; Jeffrey M Rosen
Journal: J Cell Biol Date: 2005-11-21 Impact factor: 10.539

8. Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma.

Authors: Zhe Jiang; Eldad Zacksenhaus
Journal: J Cell Biol Date: 2002-01-03 Impact factor: 10.539

Review 9. Signalling to eIF4E in cancer.

Authors: Nadeem Siddiqui; Nahum Sonenberg
Journal: Biochem Soc Trans Date: 2015-10 Impact factor: 5.407

Review 10. New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists.

Authors: Hetty Carraway; Manuel Hidalgo
Journal: Breast Cancer Res Date: 2004-08-12 Impact factor: 6.466