BACKGROUND: Limited data are available on the changes that occur at the dilated site late after coronary angioplasty. The aim of this study was to evaluate with quantitative angiography the natural history of changes that occur in the dilated segment between "early" (approximately 6 months) and "late" (approximately 5 years) follow-up after angioplasty. METHODS AND RESULTS: Of 127 consecutive patients (174 lesions) with successful angioplasty, 125 underwent early angiography. Three patients subsequently died, and 24 underwent revascularization surgery or repeated angioplasty, giving a study-eligible population of 98 patients. Quantitative angiographic analysis was performed before and immediately after angioplasty and at early and late follow-up in the study population of 84 patients (115 lesions), which was 86% of study-eligible patients. Mean lesion diameter stenosis decreased from 36.3+/-14.2% at early to 29.6+/-13.5% at late follow-up (P<.0001). No lesion developed late restenosis by the 50% diameter loss criterion. Late regression was related to stenosis severity at early angiography (r=-.58, P<.001). Subgroups at early angiography of 40% to 49% stenosis and > or = 50% stenosis showed significant regression at late angiography. CONCLUSIONS: Lesion regression at the dilated site is common late after angioplasty. The more severe a stenosis is at early angiography, the more likely the chance that there will be late regression. A strategy of watchful waiting may be appropriate for patients with restenotic lesions of borderline severity.
BACKGROUND: Limited data are available on the changes that occur at the dilated site late after coronary angioplasty. The aim of this study was to evaluate with quantitative angiography the natural history of changes that occur in the dilated segment between "early" (approximately 6 months) and "late" (approximately 5 years) follow-up after angioplasty. METHODS AND RESULTS: Of 127 consecutive patients (174 lesions) with successful angioplasty, 125 underwent early angiography. Three patients subsequently died, and 24 underwent revascularization surgery or repeated angioplasty, giving a study-eligible population of 98 patients. Quantitative angiographic analysis was performed before and immediately after angioplasty and at early and late follow-up in the study population of 84 patients (115 lesions), which was 86% of study-eligible patients. Mean lesion diameter stenosis decreased from 36.3+/-14.2% at early to 29.6+/-13.5% at late follow-up (P<.0001). No lesion developed late restenosis by the 50% diameter loss criterion. Late regression was related to stenosis severity at early angiography (r=-.58, P<.001). Subgroups at early angiography of 40% to 49% stenosis and > or = 50% stenosis showed significant regression at late angiography. CONCLUSIONS: Lesion regression at the dilated site is common late after angioplasty. The more severe a stenosis is at early angiography, the more likely the chance that there will be late regression. A strategy of watchful waiting may be appropriate for patients with restenotic lesions of borderline severity.
Authors: Y Takeda; T Kobayashi; N Awata; S Sato; J H C Reiber; T Nakagawa; E Tsuchikane; O Katoh; M Kirino; T Kobayashi; K Yachiku; N Shibata Journal: Heart Date: 2004-10 Impact factor: 5.994
Authors: Iñigo Lozano; Carlos Cuellas; Pablo Avanzas; Armando Pérez de Prado; Concepción Suárez; Juan Rondan; Daehyun Lee; Jesus M de la Hera; Felipe Fernández; César Morís Journal: Tex Heart Inst J Date: 2011
Authors: C-K Wong; C J K Hammett; R The; J K French; W Gao; B J Webber; J M Elliott; A W Hamer; J A Ormiston; M W I Webster; R A H Stewart; R V Ameratunga; H D White Journal: Heart Date: 2004-11 Impact factor: 5.994
Authors: C Michael Gibson; Ajay J Kirtane; Sabina A Murphy; Juhana Karha; Christopher P Cannon; Robert P Giugliano; Mathew T Roe; Robert A Harrington; E Magnus Ohman; Elliott M Antman Journal: J Thromb Thrombolysis Date: 2003-06 Impact factor: 2.300
Authors: Carlos M Campos; Takashi Muramatsu; Javaid Iqbal; Ya-Jun Zhang; Yoshinobu Onuma; Hector M Garcia-Garcia; Michael Haude; Pedro A Lemos; Boris Warnack; Patrick W Serruys Journal: Int J Mol Sci Date: 2013-12-16 Impact factor: 5.923