Literature DB >> 9243049

Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections.

I Raad1, A Buzaid, J Rhyne, R Hachem, R Darouiche, H Safar, M Albitar, R J Sherertz.   

Abstract

Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.

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Year:  1997        PMID： 9243049     DOI： 10.1086/514518

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  17 in total

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4.  Vancomycin-resistant Enterococcus faecium: catheter colonization, esp gene, and decreased susceptibility to antibiotics in biofilm.

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7.  Comparative in vitro efficacies of various catheter lock solutions.

Authors:  Robert J Sherertz; Michael S Boger; Casey A Collins; Lori Mason; Issam I Raad
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8.  Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilm.

Authors:  Issam Raad; Hend Hanna; Tanya Dvorak; Gassan Chaiban; Ray Hachem
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Review 9.  Prevention of central venous catheter-related infection in the intensive care unit.

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Journal:  Crit Care       Date:  2010-03-09       Impact factor: 9.097

10.  In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces.

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Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191
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